摘要
目的探讨循环血胰岛素样生长因子-Ⅰ(IGF-Ⅰ)在非小细胞肺癌(NSCLC)发展中的作用及其临床意义。方法运用双抗夹心酶联免疫吸附反应定量检测80例原发性NSCLC患者和45例肺良性疾病患者循环血中IGF-Ⅰ,分析循环血IGF-Ⅰ水平与临床病理特征的相关性。结果NSCLC组循环血IGF-Ⅰ水平显著高于肺良性疾病组;NSCLC患者循环血中IGF-Ⅰ水平在肿瘤直径≥3cm组显著高于直径<3cm组,在伴局部淋巴结转移组显著高于无局部淋巴结转移组,在晚期(Ⅲ～Ⅳ)组显著高于早期(Ⅰ～Ⅱ)组。结论IGF-Ⅰ可能以自分泌和/或旁分泌的方式促进NSCLC恶性进展,其自分泌和/或旁分泌水平与肿瘤大小、病理分期和淋巴结转移相关,体积大、分期晚、伴淋巴结转移的肺癌能分泌更多的IGF-Ⅰ。检测循环血IGF-Ⅰ水平对辅助判断NSCLC的分期可能有应用前景。
Objective To explore the role of circulating insulin-like growth factor-Ⅰ（IGF-Ⅰ）in non-small cell lung cancer（NSCLC）progression and its clinical significance.Methods Blood circulating IGF-Ⅰ levels in 80 patients with NSCLC and 45 patients with benign pulmonary diseases were measured by using enzyme linked immunosorbent assay（ELISA）and the relationship between IGF-Ⅰ level and clinicopathological parameters was analyzed.Results Blood circulating IGF-Ⅰ level was significantly higher in patients with NSCLC than in those with benign pulmonary diseases.Blood circulating IGF-Ⅰ was significantly higher in patients with NSCLC with advanced stages（stages Ⅲ and Ⅳ）or with the tumor diameter no less than 3 cm or with regional lymphoid node metastasis than in those with early stages（stages Ⅰ or Ⅱ）or with the tumor diameter less than 3 cm or without regional lymphoid node metastasis.Conclusion IGF-Ⅰ may promote malignant progression of NSCLC in autocrine and/or paracrine manner.The autocrine and/or p多aracrine level of IGF-Ⅰ is correlated with tumor diameter,tumor stage and regional lymphoid node metastasis.NSCLC with advanced stages,larger size and regional lymphoid node metastasis may secret more IGF-Ⅰ.Measurement of circulating IGF-Ⅰ may have clinical value to assess stages of NSCLC.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2009年第6期821-823,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
教育部留学回国人员科研启动基金(No.[2005]55)
湖北省自然科学基金(No.2004ABA194)资助项目
关键词
非小细胞肺癌
胰岛素样生长因子-Ⅰ
酶联免疫吸附实验
non-small cell lung cancer
insulin-like growth factor-Ⅰ
enzyme linked immunosorbent assay
