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瑞芬太尼复合靶控异丙酚对气管插管期间脑电双频指数的影响 被引量:1

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摘要 目的观察靶控异丙酚复合瑞芬太尼对成人气管插管脑电双频指数(bispectral index,BIS)的影响。方法选择需全麻的择期手术成人患者40例,分为瑞芬太尼组(R)、芬太尼组(F)两组,每组20例。麻醉诱导用咪唑安定0.05mg/kg,异丙酚血浆靶控输注,靶浓度2.0μg/ml,阿曲库铵0.6mg/kg。R组缓慢推注瑞芬太尼1.0μg/kg后以0.1μg/(kg.min)持续推注10min。F组一次性缓慢注射芬太尼5μg/kg。观察记录基础值(T1)、麻醉诱导后气管插管前(T2)、插管后2min(T3)、5min(T4)、10min(T5)各时点BIS值的变化、不良反应出现情况。结果两组BIS相应时间点与其T1比较均明显降低(P<0.05)。两组T3与其T2对应值比较BIS值均增加,。结论全麻诱导,异丙酚以2.0μg/ml血浆靶控浓度,合用1.0μg/kg瑞芬太尼并以0.1μg/(kg.min)持续推注时,可基本抑制气管插管反应。
出处 《中国实用医药》 2009年第36期152-153,共2页 China Practical Medicine
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