摘要
目的探讨^99Tc^m-甲氧基异丁基异腈（MIBI）静息心肌灌注显像在川崎病心肌缺血及疗效评价中的临床价值。方法31例川崎病患儿根据病程分为急性发热期15例、亚急性期9例和恢复期7例3组。对照组5例患儿系怀疑川崎病而行^99Tc^m-MIBI静息心肌灌注显像，后经实验室检查排除川崎病和其他心肌疾病者。所有病例均行^99Tc^m-MIBI静息心肌灌注显像，部分静息心肌灌注显像阳性者于治疗后6～12个月随访复查，并与其临床转归进行比较。结果对照组静息心肌灌注显像未见异常。31例川崎病患儿静息心肌灌注显像阳性率为41．9％（13／31）。其中急性期、亚急性期和恢复期患儿的阳性数分别为6／15例、4／9例和3／7例。其中8例显像阳性者治疗后6～12个月静息心肌灌注显像复查结果显示：缺血明显改善3例，恢复正常4例，1例仍见明显心肌缺血。结论^99Tc^m-MIBI静息心肌灌注显像能无创、直接、客观地评价川崎病心肌缺血，对川崎病心肌缺血的诊断和随访有一定的临床价值。
Objective ^99 Tc^m-methoxyisobutylisonitrile （MIBI） myocardial perfusion imaging was undertaken to detect myocardial ischemia in children with Kawasaki disease in order to evaluate its diagnostic value, Methods Thirty-one children with Kawasaki disease were included. Five children without cardiovascular disease were enrolled as control group. Of these 31 study subjects, there were classified into three groups according to their clinical manifestations. There were acute phase （ n = 15 ）, sub-acute phase （ n = 9）, and chronic phase （n = 7）. ^99 Tc^m-MIBI myocardial perfusion SPECT imaging was proformed in all patients. Eight patients with positive result repeated their SPECT imaging during 6- 12 months after their first scan. Results Thirteen of 31 （41.9%） patients were positive in MIBI perfusion imaging. Six （6/15） were at acute phase, 4 （4/9） were at sub-acute phase, and 3 （3/7） were at chronic phase. Of the 8 patients had second MIBI scans, 4 were normal, 3 improved significantly, only 1 unchanged. Conclusion ^99 Tc^m-MIBI myocardial perfusion imaging is a useful noninvasive method for diagnosis evaluation of myocardial ischemia in Kawasaki disease.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2009年第6期376-378,共3页
Chinese Journal of Nuclear Medicine
