美罗华对人淋巴瘤细胞辐射敏感性的影响
摘要
美罗华是一种人鼠嵌合的CD20抗体，是美国食品药品管理局第1个批准用于治疗非霍奇金淋巴瘤的单克隆抗体。大量的体外数据和前临床研究已经证明美罗华增加化疗反应的机制可能与抗体依赖细胞介导的细胞毒作用（ADCC）、补体依赖细胞毒作用（CDC），以及CD20介导的直接跨膜信号导致肿瘤细胞凋亡和生长抑制有关。但是，有不到50％的患者会出现美罗华耐药，所以，寻求新的治疗策略和美罗华作用的机制，对改善淋巴瘤患者的预后十分必要。目前国内尚未见到美罗华在放射治疗中的作用报道，
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2009年第6期603-606,共4页
Chinese Journal of Radiological Medicine and Protection
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