摘要
目的:探讨survivin在乳腺癌的发生、发展过程中的作用及survivin与突变型p53基因表达的相关性。方法:采用免疫组织化学ABC法检测20例正常乳腺组织、42例乳腺癌组织中survivin和p53基因的表达情况。结果:乳腺癌组survivin和P53的阳性率显著高于正常组(P<0.01,P<0.05)。结论:survivin蛋白的异常表达与乳腺癌的发生与发展密切相关,与乳腺癌的组织类型、临床分期和淋巴结转移状况无显著相关。p53基因突变出现于癌变早期,并参与乳腺癌的发生与发展。
Objective To explore the role of the survivin in the occurrence and development of the bresat cancer and its correlation with mutant p53 gene expression.Methods The survivin and p53 gene expressions were detected with the immunohistochemical ABC method in 20 cases of normal breast tissue and 42 cases of breast cancer tissue.Results The positive rates of survivin and p53 were significantly higher in breast cancer group than those in normal group （P0.01）.Conclusion The abnormal expression of survivin protein is closely correlated with the occurrence and development of breast cancer,and not correlated with histological type,clinical stage or lymph node metastasis.p53 gene mutation can be seen in the early stage of cancer,and participates in breast cancer occurrence and development.
出处
《中华实用诊断与治疗杂志》
2009年第12期1181-1182,共2页
Journal of Chinese Practical Diagnosis and Therapy
