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急性脑梗死证候要素与凝血因子的相关性研究 被引量:13

Correlation between coagulation factors and TCM syndrome elements of acute cerebral infarction
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摘要 目的探讨急性脑梗死证候要素与凝血因子的相关性。方法对148例急性脑梗死患者按照《中风病辨证诊断标准(试行)》进行证候要素评分,评分≥7分证候要素诊断成立,分为风、火、痰、血瘀、气虚、阴虚阳亢6个证候要素组,检测凝血因子凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)含量,运用等级相关分析方法研究证候要素分值与凝血因子的相关性。结果气虚组PT值低于血瘀组、风组(P<0.05),其余各组间PT值以及各组间APTT、FIB值比较无明显差异(P>0.05)。风、火证候要素分值与FIB值具有负相关性(P<0.05);痰、气虚证候要素分值与PT值具有负相关性(P<0.05,P<0.01)。结论风、火证候要素评分分值越高,纤维蛋白原含量相对降低,血液可能呈相对低凝状态;痰、气虚证候要素评分分值越高,凝血酶原时间相对缩短,血液可能呈相对高凝状态。 Objective To investigate the correlation between the coagulation factors and TCM syndrome elements of acute cerebral infarction(ACI).Methods The syndromes of 148 patients with ACI were scored according to Diagnostic Criteria for Syndrome Differentiation of Stroke(Trial Implementation).If the score was higher or equal to 7,the diagnosis was tenable.There were 6 syndrome element groups including wind,fire,phlegm,blood stasis,qi deficiency and yin deficiency with yang hyperactivity.The prothrombin time(PT),activated partial thromboplastin time(APTT) and fibrinogen(FIB) were detected and the correlation between TCM syndrome elements and coagulation factors was studied by applying rank-correlation analytic method.Results The value of PT in qi-deficiency group was lower than that in blood-stasis or wind group(P〈0.05),and was not different compared with that in other groups.The value of APTT or FIB was not different among all groups(P〉0.05).There was a negative correlation between values of FIB and wind or fire syndrome element(P〈0.05),and a negative correlation between values of PT and phlegm or qi-deficiency syndrome element(P〈0.05,P〈0.01). Conclusion The higher of the scores of wind and fire elements were,the lower of FIB was,and the patient may be in hypocoagulable state.The higher of the scores of phlegm and qi-deficiency elements were,the lower of PT was,and the patient may be in hypercoagulable state.
出处 《北京中医药大学学报》 CAS CSCD 北大核心 2009年第11期779-781,共3页 Journal of Beijing University of Traditional Chinese Medicine
基金 国家重点基础研究发展计划(973计划)资助项目(No.2006CB504805)
关键词 急性脑梗死 证候要素 凝血因子 相关性 acute cerebral infarction TCM syndrome elements coagulation factors correlation
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