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不同粒径马钱子粉体中士的宁在大鼠体内的药代动力学研究 被引量:9

Study on pharmacokinetics of brucine from normal and ultra-micro powder of semen strychni in rats
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摘要 目的:考察马钱子超微粉体与常规粉体中士的宁在大鼠体内的药代动力学特征。方法:采用HPLC法,3P97药代动力学软件拟合药动学模型。结果:大鼠灌胃马钱子超微粉体与常规粉体后士的宁的体内过程均符合二室模型,超微粉体的Cmaxμg/L(69.26±1.40)μg/L远远大于常规粉体的(51.13±0.48),说明药材超微粉碎后能大大提高其有效成分的吸收程度。参数K、Ka、B和β值显著增大(P<0.05),T1/2β显著减小(P<0.05),说明马钱子经超微化后士的宁在大鼠体内吸收相和消除相均增大,提示马钱子超微化以后能减少其蓄积中毒。结论:马钱子超微粉碎以后,血药浓度明显升高,生物利用度提高。 Objective:To study the pharmacokinetic process ofbrucine from normal and ultra-micro powder ofsemen strychni in rat serum.Methods:HPLC techniques were used.All pharmacokinetics parameters were calculated with a 3P87 program.Results:The pharmacokinetics results indicated that the normal powder and the ultra-micro powder ofsemen strychni belonged to two compartment open model.The absorb ofbrucine was just several ten minutes, and there was no obvious difference ofTmax between normal powder and ultra-micro powder.This showed that:Brucine was some material that was easily absorbed.But we can find that Cmax increased from(51.13±0.48)μg/L to(69.26±1.40)μg/L after ultra-micro powder preparation which was quite obvious.K,Ka,B and β had a obvious increase(P〈0.05) and T1/2β decreased markedly(P〈0.05).The result showed that both ofthe absorbtion and eliminate had been enhanced after ultra-micro powder preparation and cumulation toxicity can be reduced.Conclusion:The maximum concentration in rat plasma ofbrucine from ultra-micro powder ofsemen strychni was higher than that from normal powder.
机构地区 湖南中医药大学
出处 《中华中医药杂志》 CAS CSCD 北大核心 2009年第12期1568-1570,共3页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 国家科技公关课题(No.2001BA701A43) 湖南省科技厅科研科技计划重点项目(No.06Sk2005)
关键词 马钱子 超微粉体 常规粉体 士的宁 药代动力学 Semen strychni Ultra-micro powder Normal powder Brucine Pharmacokinetics
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