摘要
目的探讨液基薄层细胞学技术(liquid-based thin-lay cytology test,TCT)在筛查宫颈病变中的价值。方法回顾性分析2007年6月￣2008年9月在我院行TCT检查的1508例妇女,对其中148例结果异常的患者行阴道镜检查和定位活检病理组织学检查。比较TCT检查结果和组织学检查结果,计算TCT结果对宫颈病变的阳性预测值,评价其在筛查中的作用。结果TCT结果为不典型鳞状上皮(atypical squamous cells of undetermined signification,ASCUS)103例患者中,阴道镜活检病理为慢性宫颈炎79例,宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)Ⅰ19例,CINⅡ3例,CINⅢ2例,无宫颈癌。低度鳞状上皮内病变(low grade squamous intraepithelial lesion,LSIL)24例,其中慢性宫颈炎7例,CINⅠ9例,CINⅡ5例,CINⅢ2例,宫颈鳞癌1例,阳性预测值为70.8%。高度鳞状上皮内病变(high grade squamous intraepithelial lesion,HSIL)19例,慢性宫颈炎0例,CINⅠ4例,CINⅡ8例,CINⅢ6例,宫颈鳞癌1例,阳性预测值为100%。2例TCT结果为鳞状细胞癌患者经病理证实全部为宫颈鳞癌。结论TCT对宫颈上皮内瘤样病变有较高的敏感性,结合阴道镜定位活检,有利于宫颈癌和癌前病变的早期发现和治疗。
Objective To assess the value of thin liquid-based cytology test（TCT） in screening cervical lesions. Methods A retrospective analysis was carried out in 1508 cases of women who were checked by using the TCT from June 2007 to Sept. 2008 in our hospital,and 148 cases of abnormal results were undergone colposcopy and positioning biopsy for histopathological examination. The results of TCT were compared with histology results to calculate the positive predictive value of TCT. Results In 103 cases of atypical squamous cells of undetermined signification（ASCUS）, colposcopy biopsy pathology showed 79 cases of chronic ceivicitis, 19 cases of cervical intraepithelial neoplasia（CIN） Ⅰ ,3 cases of CIN Ⅱ ,2 cases of CIN Ⅲ and no cervical cancer. In 24 cases of low grade squamous intraepithelial lesion（LSIL）,there were 7 cases of chronic cervicitis,9 cases of CIN Ⅰ ,5 cases of CIN Ⅱ ,2 cases of CIN Ⅲ and one case of cervical squamous cell carcinoma,with the positive predictive value of LSIL of 70.8%. In 19 cases of high grade squamous intraepithelial lesion, （HSIL）,there were 4 cases of C IN Ⅰ , 8 cases of CIN Ⅱ , 6 cases of CIN Ⅲ, one case of cervical squamous cell carcinoma and no chronic cervicitis, with the positive predictive value of HSIL of 100%. TCT results showed 2 cases of squamous cell carcinoma which were all confirmed pathologically. Conclusion There is a high sensitivity in screening cervical intraepithelial neoplasia by using. TCT together with colposcopy and biopsy examination is helpful to the early detection and treatment of cervical cancer and precancerous lesions .
出处
《中国现代医生》
2009年第35期89-90,共2页
China Modern Doctor
关键词
液基薄层细胞学技术
宫颈病变
Liquid-based thin-lay cytology test（TCT）
Cervical lesion
