摘要
目的探讨输卵管妊娠保守手术治疗后持续性异位妊娠(persistent ectopic pregnancy,PEP)的预防措施及效果。方法160例行输卵管妊娠保守性手术的患者随机分为注射组(80例)与对照组(80例),均行腹腔镜下输卵管切开取胚术。注射组术中局部注射甲氨蝶呤(methotrexate,MTX)预防PEP,对照组未使用。结果注射组术后4、7、12 d血β-HCG均显著低于对照组(P<0.01)。注射组术后发生PEP 1例(1.2%),对照组6例(7.5%),组间比较有统计学差异(P<0.05)。结论腹腔镜下保守治疗输卵管妊娠,术中局部注射MTX能减少术后PEP发生率。
Objective To explore the effect of local injection of methotrexate （MTX） for preventing persistent eetopic pregnancy （PEP） during the conservative operation of tubal pregnancy. Methods 160 tubal pregnancy patients were randomly divided into injection group and control group, with 80 cases for each. During the laparoseopy of tubal pregnancy, MTX was injected locally in injection group, while not in control group. All cases were performed removal of embryo via salpingotomy. Results There was remarkable difference in the level of serum β-HCG at 4,7,12 days postoperatively between two groups （P〈0.01）. 1 case （1.2%） occurred PEP in injection group, and6 cases （7.5%） in control group ; the incidence rate of injection group was significant lower than that of control group （ P 〈 0. 05）. Conclusion Local injection of MTXcan reduce the incidence of PEP during the laparoscopic conservative surgery for tubal pregnancy.
出处
《中国现代手术学杂志》
2009年第5期365-367,共3页
Chinese Journal of Modern Operative Surgery
关键词
妊娠
输卵管
持续性异位妊娠
甲氨蝶呤
pregnancy, tubal
persistent ectopic pregnancy
methotrexate
