摘要
目的探讨不同时间应用大剂量静脉丙种球蛋白(IVGG)治疗川崎病(KD)疗效,分析其热程及冠状动脉损害(CAL)情况。方法将79例在初次发病10d内接受大剂量IVGG治疗的住院KD患儿按IVGG应用时间不同分成两组,≤6d为A组(32例),7～10d为B组(47例);将两组CAL情况及其他临床资料进行对比分析。结果两组病例性别、年龄、ESR、CRP、WBC、HGB、PLT、ALB均衡可比。两组热程比较A组(7.00±0.87)d短于B组(9.00±1.00)d,差异有显著性(P<0.001);A组无CAA发生,B组2例发生CAA;发病21d内CAL发生率A组37.5%(12例)低于B组46.8%(22例),差异无统计学意义(P=0.412)。结论KD发病早期应用IVGG治疗,可缩短热程,减少CAA发生。建议KD确诊病例尽早应用大剂量IVGG治疗。
Objectives： The aim of this analysis was to determine the optimal period of intravenous gamma- globulin （IVGG） treatment in Kawasaki disease （KD）. Methods： We selected 79 patients who received IVGG treatment within 10 days of illness. We divided these patients into 2 groups： A group （treated on days 1 -6：32 cases） and B group （days 7 - 10：47 cases）. We compared the rate of prevalence of coronary artery lesions （CAL） between these groups and analyzed the clinical features. Results ： There were no significant differences between the 2 groups regarding the sex, age, ESR, CRP, WBC, HGB, PLT and albumin. The period of fever in group A was significantly shorter than those of group B [ （7.00±0. 87） d vs （9.00± 1.00） d, P 〈0. 001 ） ]. There were 2 cases with coronary artery aneurysm （CAA） in group B, and none in group A. There were no significant differences in coronary artery lesions between the two groups （37.5% vs 46. 8%, P =0. 412） within 21 days. Conclusions： Early IVGG treatment is likely to shorten the period of fever and preventing CAA in KD. We recommend giving IVGG treatment to KD as early as possible.
出处
《中国优生与遗传杂志》
2009年第12期118-119,共2页
Chinese Journal of Birth Health & Heredity
关键词
粘膜皮肤淋巴结综合征
丙种球蛋白
治疗
Mucocutaneous lymph node syndrome
Intravenous gamma globulin
Therapy
