摘要
【目的】探讨双胎脐血维生素D水平与孕母维生素D营养状况的关系，进行孕期营养指导。【方法】以2008年3月～2009年3月分娩的37对双胞胎和双胎母亲为研究对象，测定脐血与分娩时母亲血清25羟-维生素D3[25-（OH）D3]水平，对双胎孕妇于孕4～6月、分娩前进行膳食指导、膳食调查和问卷调查。【结果】双胎儿脐血25-（0H）D。水平为（66．59±32．04）nmol／L；对应母血水平为（67．70±34．39）nmol／L。脐血与母血之间、双胎脐血之间均数比较，差异均无显著性。母血正常组，母血与脐血水平呈正相关（r=0．83，P〈0．01）；母血低常组，母血与脐血水平呈负相关（r=-0．71，P〈0．01）。母孕期平均每日户外活动时间（r=0．85，P=0．00）；每天进食含有维生素D食物的种类（r=0．52，P=0．04）；孕期补充维生素D史（F=7．55，P=0．01）与母血25-（OH）D。水平有关。母血、脐血25-（OH）D3均正常的孕母孕期平均每日户外活动时间为（1．98±0．82）h；每天进食含有维生素D的食物的种类为（2．01±0．76）种，有服用维生素D制剂的占80％。【结论】双胎脐血维生素D水平与孕母维生素D营养状况密切相关；为维持孕母、胎儿维生素D的正常水平，双胎孕母孕期应采取综合预防措施。
[Objective] To explore the relationship of vitamin D level in twins umbilical vein and vitamin D nutri tional status of pregnant women in Nanjing. [Methods] A total of 37 twin pairs[15 monozygotie（MZ） and 22 dizygotie （DZ）] were recruited from Jiangsu Province Hospital. 25-（OH）D in maternal serum and umbilical vein serum were detec ted, and dietary survey of pregnant women and questionnaire were investigated to obtain information about vitamin D supplementation,sunlight exposure, and dietary vitamin D intake. Diet were guided. [Results] Maternal 25 （OH）D levels [-（67.70±34.39）nmol/L] were higher than umbilical venous blood concentrations [（66. 59±32.04）nmol/L]. A strong positive correlation was observed between maternal and umbilical 25-（OH）D concentrations when maternal serum 25-（OH） D were higher than 27.5 nmol/L（r=0.83,P〈50.01） and negatively correlated when under 27.5 nmol/L（r=-0. 71 ,P〈0.01 ）. There was no significant difference between interpairs＂ umbilical vein serum. The value of maternal serum 25-（OH） D were correlated with sun exposure（r=0.85,t=5.05,P=0.00） ,kinds of vitamin D-contained food（r=0.52,t=2.20,P = 0.04）, complementing vitamin D（F=7.55, P = 0.01 ） during pregnancy. The difference of sun exposure, complementing vitamin D ,kinds of vitamin D-contained food had significance between normal group and abnormal group of 25-（OH）Da in maternal serum. Sun exposure, kinds of vitamin D- vitamin D food were （1.98 ± 0.82）h/d and （2.01 ± 0.76 ）kinds, respec tively in normal group of maternal serum. 80%0 of normal group＇ mothers used any supplemental vitamin D and only 200/00 of abnormal group used any supplemental vitamin D. [Conclusions] The level of vitamin D in twins＇ umbilical vein is closely related to vitamin D nutritional status of pregnant women. To maintain normal levels of vitamin D in maternal serum and umbilical vein serum of twins, pregnant women should adopt integrative preventions.
出处
《中国儿童保健杂志》
CAS
2009年第6期629-631,共3页
Chinese Journal of Child Health Care
关键词
脐血
孕妇
维生素D
营养
指导
umbilical vein serum
pregnant women
vitamin D
nutrition
propose
