摘要
目的:探讨乳腺癌组织中EZRIN蛋白的表达,并分析其与乳腺癌病理因素的关系。方法:采用ABC免疫组化染色法,检测乳腺癌及乳腺良性病变组织(对照组)中EZRIN蛋白的表达。结果:EZRIN蛋白在乳腺癌中的阳性率为60.78%(62/102),在乳腺良性病变中的阳性率为16.67%(5/30),两者差异有统计学意义(P<0.01);EZRIN的表达与乳腺癌分化程度、肿瘤细胞淋巴结转移和患者TNM分期相关(P<0.05)。结论:EZRIN对乳腺癌的增殖、生长、侵袭和转移起重要作用,有望成为肿瘤治疗的新靶点。
Objective： To investigate the expression of EZRIN in breast carcinoma and analyze the relation with pathologic factors of breast cancer. Methods： ABC immunohistochemicalstaining method were used to detect the expressions of EZRIN protein respectivdy, in breast cancer and benign breast lesion.Results： The positive rate of EZRIN proteinin breast carcinoma （62/102, 60.78% ） was significantly higher than that in benign mammary lesion （5/30, 16.67 % ） （ P 〈 0.01 ）, and the expression of EZRIN was correlated with the degree of differentiation, lymph node metastasis and T NM stageof breast cancer （P 〈 0.05 ）. Conclusion： EZRIN play an important role in the proliferation, growth, invasiveness and metastasis of breast cancer, and could potentially be the novel targets in the treatment of breast cancer.
出处
《中国民康医学》
2009年第24期3090-3091,共2页
Medical Journal of Chinese People’s Health
