摘要
目的:通过分析乳腺浸润性导管癌的X线表现,预测乳腺浸润性导管癌的雌激素受体(ER,estrogen receptor)、孕激素受体(PR,progesterone receptor)、人类上皮生长因子受体-2(C-erbB-2,human epithelium growth receptor 2)的表达。方法:选择30例资料完整的乳腺浸润性导管癌患者,术后对标本进行免疫组织化学染色并判断这些免疫因子的表达情况;将X线表现中的肿块伴有的恶性钙化、肿块边缘的毛刺和有无合并乳腺腺体增生症与ER、PR及C-erbB-2表达情况进行对比分析。结果:毛刺组的ER阳性率较无毛刺组高(P<0.05);伴有腺体增生症组ER阳性率较无腺体增生症者高(P<0.05);钙化组的C-erbB-2阳性率较无钙化组高(P<0.05)结论:通过对乳腺癌钼靶X线征像的分析可以反映ER、PR及C-erbB-2的表达情况,指导临床治疗和效果评价。
Objective： To predict the expression levels of estrogen receptor （ ER）, progesterone receptor （PR） and human epithelium growth receptor - 2 （ C - erbB - 2 ） by analyzing the molybdenum target X - ray manifestations of invasive ductal carcinoma. Methods ： 30 patients with invasive ductal carcinoma were selected, and the expression levels of immune factors were detected by immunohistochemistry; X -ray manifestations of lumps with malignant calcification, specula and complicated with mammary hyperplasia or not were compared with expression levels of ER, PR and C - erhB - 2. Results ： The positive rate of ER in specula group was higher than that in non - specula group （ P 〈 0. 05 ） . The positive rate of ER in lesions with mammary hypeFplasia was higher than that in lesions without mammary hyperplasia （ P 〈 0. 05 ） . The positive rate of C - erbB - 2 in calcification group was higher than that in non - calcification （ P 〈 0. 05 ） . Conclusion ： The analysis of molybdenum target X - ray manifestations of invasive ductal carcinoma can reflect the expression levels of ER, PR and C - erbB -2, which may direct clinical treatment and efficacy evaluation.
出处
《中国妇幼保健》
CAS
北大核心
2009年第36期5209-5211,共3页
Maternal and Child Health Care of China
关键词
乳腺浸润性导管癌
钼靶X线表现
雌激素受体
孕激素受体
人类上皮生长因子受体-2
Invasive ductal carcinoma
Molybdenum target X -ray manifestations
Estrogen receptor
Progesterone receptor
Human epithelium growth receptor- 2
