摘要
目的观察祛瘀合剂对血瘀证大鼠血液流变学的影响。方法将60只Wistar大鼠随机分为空白对照组、血瘀证模型组、生化汤颗粒组(中药对照组)和祛瘀合剂高、中、低剂量组,采用肾上腺素(Adr)皮下注射及冷冻刺激诱发大鼠血瘀证模型,用放射免疫法测定样品的全血还原黏度低、中、高切,红细胞压积,血沉,血沉方程K值,红细胞聚集指数,红细胞刚性指数,红细胞变形指数,红细胞电泳指数等指标。结果造模后大鼠红细胞压积,全血还原黏度低、中、高切,血沉、血沉方程K值,均明显升高(P<0.05);祛瘀合剂对上述指标均有明显降低(P<0.05)。结论祛瘀合剂能明显改善血瘀证血液流变性,消除血液浓、粘、凝的状态。
Objective To observe the effects of Quyu Mixture（ Quyu Heji, QYHJ） on the hemorheology indicators in rat models with blood stasis syndrome（BSS） and to explore its mechanisms. Methods The rats were equally divided into six groups randomly ：the normal group , the model group , the herbal control group （ given Shenghua Granule）, high dose, medium dose and low dose of QYHJ groups. The rats models with BSS were induced by injection of Adrenine（Adr） and instigation of ice. With the radioimmunoassay,we observed 10 indexes, such as the whole blood viscosity reduction low -cut,middle -cut and high -cut;PCV, ESR, k -value equation ESR, RBC conglomeration index, RBC rigid index,RBC deformation index and RBC electrophoresis index. Results The PCV and the whole blood viscosity reduction low - cut,middle - cut, k- value equation ESR and ESR all increased with a very significant statistical significance（ P 〈0.05 ） between the model group and the control group. After using QYHJ, the indexes were decreased compared with the model group,except the whole blood viscosity reduction high - cut and RBC deformation index. Conclusion QYHJ can significantly improves the hemoheology, attenuated the status of thick, sticky, condensate of blood.
出处
《湖北中医学院学报》
2009年第6期18-20,共3页
Journal of Hubei College of Traditional Chinese Medicine
基金
湖北中医学院大学生创新研究基金项目
[2008J002]
关键词
血瘀证
祛瘀合剂
血液流变学
blood stasis syndrome（BSS） ,QYHJ , the hemorheology
