摘要
目的:研究克癌新及其组分对荷瘤小鼠肿瘤生长的影响,探讨其组方的合理性。方法:建立小鼠肉瘤S180和小鼠肝癌H22移植性肿瘤模型,以瘤重抑制率为指标观察克癌新及其组分对荷瘤小鼠肿瘤生长的影响。结果:克癌新150 mg.kg-1与300 mg.kg-1对小鼠肉瘤S180的生长抑制率分别为38.52%与47.88%;对肝癌H22生长抑制率分别为32.17%与40.18%;其抑瘤作用明显强于各组分(P<0.05)。结论:克癌新能产生显著协同抗肿瘤作用,组方较合理。
Objective： To study the effects of keaixin and its components on the tumor growth in tumor-bearing mice. Methods：The inhibitory effect on tumor growth was observed by the models of implanted sarcoma180（S180） and hepatorna 22（H22 ） in mice. Result： At dosage of 150 and 300 mg ·kg^-1 , the inhibitory rate of Keaixin is 38.52% and 47.88% for S180, 32. 17% and 40.18% for H22, respectively. The effects of Keaixin were superior to its components（P〈0. 01 or P〈0. 05）. Conclusion： Keaixin exhibited significantly anti-tumor synergistic effect, its prescription is reasonable.
出处
《四川生理科学杂志》
2009年第4期147-149,共3页
Sichuan Journal of Physiological Sciences
基金
四川省教育厅重点项目(2005A076)
