摘要
目的探讨血栓闭塞性脉管炎TAO的发病机制,为临床诊断、治疗提供依据。方法应用红细胞葡萄球菌蛋白A混和花环试验对76例TAO病人和55名正常人外周血进行了红细胞免疫功能测定,同时对其SOD和LPO的含量进行了检测。结果急性期TAO病人和正常对照相比较,RBCC3bRR明显降低(P<001),而RBC—ICRR则明显升高(P<001),而稳定期病人与正常对照无显著变化,TAO患者活动期和稳定期SOD含量均降低,血清LPO浓度均升高。结论TAO患者存在着红细胞免疫功能异常,同时体内抗氧化能力降低、脂质过氧化物损伤也导致了红细胞免疫调节功能异常。
Objective To explore the pathogenesis of TAO in order to provide basis for clinical diagnosis and treatment Method Immunologic function of red cells in peripheral blood from 76 cases of TAO and 55 normal people was detected by mixed rosette test of RBC staphylococcal protein A,and the contents of SOD and LPO were also detected Results When the patients were at stage ,activity of RBC c3b receptor was remarkably reduced (P<0.01)while the rate of RBC immune complex rosette was increased (P<0.01).However,there was no obvious difference between the patients at stable stage and normal people .The level of SOD in active and stable stage was decreased while LPO level increased Conclusion The immunologic function of red cells in patients with TAO was abnormal ,which may be resulted from the reduction of antioxide ability and injuried LPO.
出处
《泰山医学院学报》
CAS
1998年第3期214-217,共4页
Journal of Taishan Medical College
关键词
血栓闭塞性
脉管炎
红细胞免疫
过氧化物脂质
thrombangitis obliterans (70)
immunologic function of red cell
complex rosette