摘要
目的:为正确诊断和治疗药源性肾病,对58例该病患者进行了调查分析.方法:根据用药史、临床症状、尿、肾功能检验等以及停药后效应、排除原发病等作出综合诊断.结果:在引起药源性肾病的有关药物中,氨基糖戒类43.10%,头孢菌素类13.79%,解热镇痛类29.31%,横胺类8.62%,抗结核类3.45%.临床分类中单纯性血尿43例,单纯性白尿8例,血尿、蛋白尿混合性4例,急性肾功能不全3例.结论:在儿科临床使用上述药物时要注意进行尿液监测,一旦明确诊断,应立即停用有关药物.
For better diagnosis and treatment of medicamentous nephropathy, 58 patients with medicamentous nephropathy were investigated for the causes of the disease. Diagnosis was established in the patients on the basis of drug-treatment history, clinical symptoms, results of urine and kidney tests, effect after drug withdrawal and exclusion of primary disease. Our results showed that the drugs that can cause nephropathy included aminoglycoside antibiotics(43.10%) , cephalosporins(13.79%), antipyretic analgesics (29-31%), sulfonamides (8.62%) and anti-tuberculosis agents (3-45%). Clinical manifestations included simple hematuria(n=43), simple proteinuria(n=8) and hematuria/proteinuria(n=4), and acute renal insuf-ficiency(n=3). In the clinical practice, urine tests have to be conducted when the above-mentioned agents are used in chidren. Once the diagnosis of renal damage is established, the involved drugs have to be discontinued.
出处
《药物流行病学杂志》
CAS
1998年第3期149-150,157,共3页
Chinese Journal of Pharmacoepidemiology
