摘要
目的：妊娠期高血压疾病（HDCP）具有远期不利影响。研究HDCP患者认知功能的变化，并探讨其机制。方法：选择HDCP患者53例，分为妊娠期高血压组（20例）、轻度子痫前期组（18例）和重度子痫前期组（15例），选择正常产妇22例为对照组。所有研究对象在分娩后60～80d内进行认知功能检查。认知功能测定包括听觉词语学习及延迟回忆、数字广度、言语流畅、积木测验、连线测验A、符号数字替换测验。结果：重度子痫前期组患者的词语学习（P〈0．01）、符号数字替换测验（P〈0．05）、连线测验A（P〈0．05）较对照组显著下降。结论：重度子痫前期组患者在分娩60d后仍有认知功能损害，对其应积极治疗，并关注疾病的长期转归。
Objectives： Hypertensive disorders complicating pregnancy （HDCP） has a long -term deleterious effect. This study aimed to investigate the changes of cognitive function in women with HDCP and explore their possible mechanism. Methods： Fifty-three patients with HDCP and 22 normal pregnant women were included in this study, their cognitive functions assessed 60 -80 days after delivery by word learning and delayed recall test, symbol digit substitution test, animal category fluency test, block design, trail making test （Part A） and digit span test. The results of the cognitive tests were compared between the HDCP and normal control groups. Results ： Cognitive performances of the severe preeclampsia patients differed significantly from those of the normal individuals on the tests of word learning （P 〈 0.01 ） and symbol digit substitution （ P 〈 0.05 ） and trail making test A （ P 〈 0.05 ）. Conclusion ： Cognitive function impairment remains in patients with severe preeclampsia even 60 days after delivery, which requires active treatment and long-term observation.
出处
《医学研究生学报》
CAS
2009年第11期1175-1177,共3页
Journal of Medical Postgraduates
基金
南京军区科技创新课题基金资助(批准号:07M077)
关键词
妊娠期高血压疾病
认知功能
随访
Hypertensive disorders complicating pregnancy
Cognitive function
Follow.up
