摘要
目的观察阿德福韦酯治疗慢性乙型肝炎(慢性乙肝)的疗效。方法100例慢性乙肝患者随机分为2组,治疗组50例,对照组50例。在应用甘草酸二铵注射液,降酶保肝治疗基础上,对照组加用苦参素0.2g,每天3次口服;治疗组加用阿德福韦酯10mg,每天1次口服,疗程均为24周。观察2组在用药后ALT、HBV-DNA、HBeAg变化情况。结果治疗结束时,2组患者临床症状均有明显改善,治疗组HBV-DNA有效率84.0%及HBV-DNA阴转率66.0%均高于对照组的40.0%和16.0%,差异有统计学意义(P<0.05)。结论阿德福韦酯治疗慢性乙肝,抑制HBV-DNA的疗效明显,值得临床推广应用。
Objictive To observed the effect of adefovir dipivoxil treated with chronic hepatitis B （chronic hepatitis B）.Methods 100 cases of chronic hepatitis B were randomly divided into 2 groups,treatment group 50 cases,50 cases of the control group.On the basis of treating by diammonium glycyrrhizinate injection,decreasing related enzymes and liver protection therapy,the control group was added kushenin 0.2g,three times per day,oral,while treatment group oral adefovir dipivoxil 10mg,one time a day,treatment for 24 weeks. Observed the changes of ALT, HBV-DNA, HBeAg in the two groups after treatment. Results End of treatment, two patients showed significant improvement of clinical symptoms, HBV-DNA efficiency, 84.0% and HBV-DNA negative conversion rate of 66.0% in the treatment group were higher than that in the control group of 40.0% and 16.0%, the difference was statistically significant （ P 〈 0.05 ）. Conclusion The efficacy of inhibiting HBV-DNA about adefovir dipivoxil treated with chronic hepatitis B obviously,it is worth to promote the application of clinical.
出处
《临床合理用药杂志》
2009年第21期14-15,共2页
Chinese Journal of Clinical Rational Drug Use
