摘要
目的探讨中乌头碱C3,C13,C15位羟基的丙酰化方法。方法以中乌头碱、丙酸酐为原料合成中乌头碱酯化衍生物。结果得到4种丙酰化衍生物,并通过ESI-MS,1H-NMR验证了其结构,分别为3-丙酰基中乌头碱(a);3,13,15-三丙酰基中乌头碱(b);3-丙酰基-13,15-二乙酰基中乌头碱(c);3-乙酰基-13-丙酰基中乌头碱(d)。据文献检索,所有化合物均为首次报道。结论中乌头碱的三个羟基中,C3-OH最易被丙酰化,C15-OH最难被丙酰化。
Objective To study the propionylation method of C3-OH,C13-OH,C15-OH from mesaconitine. Methods Esterification derivatives were synthesized from mesaconitine and propionic anhydride. Results Four derivatives were synthesized. They were 3 - propionyl mesaeonitine, 3,13,15-tripropionyl mesaconitine, 3 - propionyl-13, 15-diacetyl mesaeonitine, 3-acetyl-13-propionyl mesaconitine. All the derivatives were reported for the first time recording to literature retrieval, and characterized by ESI-MS, 1H- NMR. Conclusion Among the three hydroxy groups, C3-OH is the first esterified one and the C15-OH is the last esterified one.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第12期2942-2944,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家"十一五"科技支撑重大专项课题(No.2006BAE01A01-12)
关键词
乌头
二萜生物碱
酯化反应
植物源农药
Diterpenoid alkaloids
Esterification
Botanical pesticide
