摘要
目的探讨50岁以上亲属活体供肾移植供者的安全性。方法1993年4月至2007年12月行年龄〉50（51～78）岁亲属活体供肾移植45例，同期年龄≤50岁供者62例作为对照组。比较2组供者手术前后SCr、GFR变化，手术并发症及术后随访情况。结果供肾手术均获成功。2组供者术前SCr分别为（82．16±10．86）和（78．66±10．41）μmol／L，术后1周、1个月及12个月分别为（106．00±8．68）、（86．62±10．81）、（83．18±9．19）μmol／L和（103．89±9．29）、（85．65±7．42）、（80．32±8．89）μmol／L，组间比较差异均无统计学意义（P〉0．05）；2组术前GFR分别为（85．82±6．26）和（88．74±9．44）ml／min，术后1、12个月分别为（49．76±3，57）、（60．32±4．42）ml／min和（51．36±5．39）、（62．10±6．31）ml／min，组间比较差异均无统计学意义（P〉0．05）。2组供者术后平均住院时间分别为9及8d。〉50岁组术中发生胸膜损伤2例，术后切口疼痛、下腹部麻木感4例，切口脂肪液化1例；对照组发生胸膜损伤1例，术后切口疼痛、下腹部麻木感9例。〉50岁组供者随访37（12～180）个月，肾功能正常。结论高龄不是亲属活体供肾绝对禁忌证，术前全面系统评估及术中仔细操作是高龄供者术后安全性的重要保证。
Objective To explore the safety of the elderly donors in living related donor kidney transplantation. Methods Forty-five elderly donors （51 -78 years, study group） who underwent nephrectomy for living related donor kidney transplantation from April 1993 to December 2007 were ret rospectively investigated. Clinical data including serum creatinine （SCr）, glomerular filtration rate （GFR） in pre-and post-operation, operation complications and hospital stay time were analyzed and compared with the control group（62 cases, the donors age were younger than 50 years）. Results The operations of all living donors were successful. The SCr and GFR in pre-operation were （82.16 ±10.86）btmol/L, （85.82± 6.26）ml/min（study group） and （78.66± 10.41） μmol/L, （88. 74± 9.44） ml/min （control group） respectively. There were no significant differences in SCr and GFR between the groups at different time points（P〉0.05）. The average hospitalization time was 9 days in study group and 8 days in control group. There were no severe per＋operative complications and no renal function failure was found in long-term following-up in study group. Conclusions Age is not the absolute contraindication of donor for living related donor kidney transplantation. The preoperative evaluation and careful operation can ensure the safety of elderly donors.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2009年第12期805-808,共4页
Chinese Journal of Urology
基金
基金项目：山东省科技发展计划项目（2007GG20002038）
关键词
肾移植
活体亲属供者
高龄
Kidney transplantation
Living related donor
Elderly
