摘要
目的:观察多索茶碱不同时间给药的药动学差异。方法:16只大鼠在8∶00,20∶00两个不同时间点,按80.0mg.kg-1多索茶碱口服给药,于0.08,0.25,0.5,1.0,1.5,2.0,3.0,5.0,7.0h后取血,分别测定其血浆药物浓度,并按非房室模型计算药动学参数。结果:大鼠于8∶00和20∶00给药,其药动学的主要参数t1/2、AUC(0-7)、MRT(0-7)、Vz/F、CL/F、tmax、Cmax等差异无显著性(P>0.05)。结论:多索茶碱在大鼠体内的药动学参数没有明显的昼夜节律性变化。
OBJECTIVE To observe the change of pharmacokinetics of doxofylline in rats by single oral administration at different time. METHODS Sixteen rats were given a single dose of doxofylline 80 mg·kg^-1 at 8 ： 00 and 20： 00 respectively. The blood was taken out at 0. 08,0. 25,0. 5,1.0, 1.5,2. 0,3. 0,5. 0,7. 0 h. The concentrations of doxofylline in plasma was determined and the pharmacokinetic parameters of non-compartment model were calculated. RESULTS The main pharmacokinetic parameters of doxofylline t 1/2 ,AUC（0-7）、MRT（0-7）、Vz/F、CL/F、Tmax、Cmax were not significantly different in rats by oral administration at 8：00 and 20：00（P〉0. 05）. CONCLUSION The pharmacokinetics of doxofylline has no obvious change in circadian rhythms in rats.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第23期2009-2011,共3页
Chinese Journal of Hospital Pharmacy
