摘要
目的通过比较消化性溃疡、胃炎患者及正常人胃粘膜组织一氧化氮合酶（ＮＯＳ）的活性，探讨ＮＯＳ和一氧化氮（ＮＯ）在消化性溃疡发病和转归过程中所起的作用，以及年龄因素对胃粘膜组织ＮＯＳ活性的影响。方法共收集了７８份胃粘膜标本，其中胃溃疡病人２３例，十二指肠球部溃疡２７例，浅表性胃炎１７例，正常志愿者１１例；采用高铁血红蛋白比色法检测ＮＯＳ的活性。结果胃溃疡患者ＮＯＳ活性显著高于正常对照组（Ｐ＜０．０２）；十二指肠球部溃疡患者及浅表性胃炎患者ＮＯＳ活性与正常对照组相比均无显著性差异；不同年龄组胃溃疡、十二指肠球部溃疡、胃炎患者胃粘膜组织中ＮＯＳ活性无显著性差异。结论胃溃疡患者ＮＯＳ活性升高，可能是机体为修复胃粘膜而引发的一种代偿反应，将有利于溃疡的愈合；
This study is to elucidate the significance of NOS and no in peptic ulcer and the effect of aging on the activity of NOS in gastric mucosa. 78 samples of gastric mucosa were obtained from 23 patients of gastric ulcer, 27 patients of duodenal ulcer, 17 patients of superficial gastritis, and 11 normal volunteers. The activity of NOS were measured by colorimetric method. The activity of NOS of gastric ulcer patients was found to be significantly higher than that of normal subjects(P<0 02). No significance was found in the comparison between the NOS activity of duodenal ulcer patients or superficial gastritis patients and that of normal subjects. And the activity of NOS in gastric mucosa of patients with gastric ulcer, duodenal ulcer or superficial gastritis did not change with aging. These findings suggest that in gastric ulcer patients stimulated NOS activity may be the result of compensatory reaction of the body to reconstitute the damaged gastric mucosa and it will contribute to the healing of ulcer; and that aging has no major effect on the activity of NOS in gastric mucosa.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1998年第5期266-268,共3页
Chinese Journal of Gerontology
