摘要
目的探讨云克(^(99m)Tc-亚甲基二磷酸盐,^(99m)Tc-MDP)合并化疗治疗多发性骨髓瘤骨损害,减轻病人的骨痛,促使病灶骨修复,改善病人的生活质量的疗效。方法 19例多发性骨髓瘤病人伴有骨损害、骨痛给予M_2方案或VAD方案化疗,同时辅以云克治疗骨损害,用法为250ml生理盐水溶解云克3支(16.5mg),缓慢静脉滴注2h以上,连续5天为1个疗程,隔周行第2个疗程,云克治疗前后均行骨X线或骨ECT检查,观察病人骨痛缓解和骨病灶范围减少状况,再评价其疗效。结果 19例病人中显效+有效15例(15/19,78.9%),无效4例(4/19,21.1%);通过X线或骨ECT云克治疗前后比较,发现骨病灶完全消失者3例(3/19,15.8%),骨病灶范围不同程度减少、数量减少9例(9/19,47.4%),骨病灶范围稳定或增大者7例(7/19,36.8%),总有效率63.1%(12/19)。不良反应轻微,肾功能减退者云克减量或慎用。结论云克治疗多发性骨髓瘤骨损害疗效确切,不良反应小。
Objective To study the effectiveness of Yunke（99mTc- - MDP） combination with chemotherapy for bone destruction in multiple myelama, ease patients pain, impel pathological bone restore and improve patients life quality. Methods Nineteen patients were treated with M2 or VAD regimen and Yunke（99mTc- -MDP） ,with usage being 250ml 0.9% NS and Yunke（99mTc -MDP）16.5mg intrave- nous injection slowly over 2h. Five consecutive days was regarded as one course of treatment,with interval week following course. Bone X - ray or bone ECT was examined after Yunke（ 99mTc - MDP） treatment. We observed patients bone pain ease and pathological bone scope. Results 15 cases were notable effective plus effective of 15（ 15/19,78.9% ） , and 4 no effective of 19（4/19,21. 1% ）. 3 cases bone pathological complete disappeared（ 3/19,15.8% ） and 9 cases bone pathological scope reduced （9/19,47.4%）. 7 cases bone pathologi- cal scope increased or was stable（7/19,36.8% ） by X -ray and（or） bone ECT examine. The total effective rate was 63. 1% （12/19）. The side effects were light. Yunke（99mTe -- MDP） used discreetly or reduce in kidney function lessen. Conclusion Effective is definite for Yunke（ 99mTc-- MDP）treated bone destruction in multiple myeloma and the side effects is light.
出处
《医学研究杂志》
2009年第11期69-70,共2页
Journal of Medical Research
关键词
云克
化疗
骨损害
多发性骨髓瘤
Yunke
Chemotherapy
Bone destruction
Mutiple myeloma
