期刊文献+

吸入麻醉药后处理对心肌缺血再灌注的保护机制 被引量:2

下载PDF
导出
摘要 缺血后处理指在一段长时间缺血后,再灌注开始前,通过反复、短暂、间断的缺血/再灌注而诱导的心肌保护现象。吸入麻醉药如异氟醚、七氟醚等可通过抑制线粒体通透性转换孔的开放,促进ATP敏感性钾通道的开放,激活再灌注损伤补救酶途径,减少微血管损伤,阻止心肌细胞凋亡、坏死等机制,产生类似于缺血后处理的效应。它是心肌保护的一种新途径。
出处 《国际心血管病杂志》 2009年第6期346-348,共3页 International Journal of Cardiovascular Disease
  • 相关文献

参考文献1

二级参考文献13

  • 1C. Penna,R. Rastaldo,D. Mancardi,S. Raimondo,S. Cappello,D. Gattullo,G. Losano,Dr. P. Pagliaro MD, PhD.Post–conditioning induced cardioprotection requires signaling through a redox–sensitive mechanism, mitochondrial ATP–sensitive K+ channel and protein kinase C activation[J].Basic Research in Cardiology.2006(2) 被引量:1
  • 2J. Vinten-Johansen Ph.D.,Z.-Q. Zhao,A. J. Zatta,H. Kin,M. E. Halkos,F. Kerendi.Postconditioning A new link in nature’s armor against myocardial ischemia–reperfusion injury[J].Basic Research in Cardiology.2005(4) 被引量:1
  • 3A.P. Halestrap,C.P. Connern,E.J. Griffiths,P.M. Kerr.Cyclosporin A binding in mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury[J].Molecular and Cellular Biochemistry (-).1997(1-2) 被引量:1
  • 4Bopassa, J.C,Ferrera, R,Gateau-Roesch, O,Couture-Lepetit, E,Ovize, M.PI 3-kinase regulates the mitochon-drial transition pore in controlled reperfusion and post-conditioning[].Cardiovasc Res.2006 被引量:1
  • 5de Hert S.G.,van der Linden P.J.,Cromheecke S.,Meeus R.,ten Broecke P W.,de Blier I.G,Stockman B.A,Rod-rigus, I.E.Choice of primary anesthetic regimen can influence intensive care unit length of stay after coronary surgery with cardiopulmonary bypass[].Anes-thesiology.2004 被引量:1
  • 6Eriksson, O,Pollesello, P,Saris, N.E.Inhibition of lipid peroxidation in isolated rat liver mitochondria by the general anaesthetic propofol[].Biochem Pharmacol.1992 被引量:1
  • 7Frokiaer, J,Marples, D,Valtin, H,Morris, J.F,Knepper, M.A,Nielsen, S.Low aquaporin-2 levels in polyuric DI +/+ severe mice with constitutively highcAMP-phosphodiesterase activity[].Am J Physiol.1999 被引量:1
  • 8Griffiths, E.J,Halestrap, A.P.Protection by cyc-losporin A of ischemia/reperfusion-induced damage in isolated rat hearts[].J Mol Cell Cardiol.1993 被引量:1
  • 9Griffiths, E.J,Halestrap, A.P.Mitochondrial non-specific pores remain closed during cardiac ischae-mia, but open upon reperfusion[].Biochem J.1995 被引量:1
  • 10Hausenloy, D.J,Duchen, M.R,Yellon, D.M.Inhibiting mitochondrial permeability transition pore opening areperfusion protects against ischaemia-reperfusion injury[].Cardiovascular Research.2003 被引量:1

共引文献47

同被引文献15

引证文献2

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部