摘要
目的:研究碘化壳聚糖季铵盐(TMCI)对小鼠的急性毒性作用和对大鼠的降脂作用。方法:分别给予小鼠小、大剂量(2.25、4.50g·kg-1·d-1)的TMCI7d,记录小鼠体质量;将大鼠随机分为空白组、高脂模型组、考来烯胺(CLST)组和TMCI组,后3组建立高脂模型3周,再分别给予相应药物,给药前及给药后2、4周取血测定各组大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平及体质量。结果:小、大剂量的TMCI对小鼠生长无明显影响;与给药前比较,大鼠TMCI组HDL-C水平升高,TG、TC、LDL-C降低(P<0.05或P<0.01),但作用不如CLST明显。结论:TMCI对小鼠具有良好的生物安全性,经口服给药后对高血脂模型大鼠具有一定的改善作用。
OBJECTIVE： To explore the acute toxicity on mice and lipid lowering effect on rats of N - trimethyl chitosan iodide （TMCI）. METHODS： The mice were assigned to receive TMCI at low and high doses （2.25, 4.50 g·kg-1·d-1） for 7 days, with body weight recorded. Then the rats were randomly divided into 4 groups： blank normal group, hyperlipemia model group, cholestyramine （CLST） group, and TMCI group. Hyperlipemia model was established for the latter 3 groups before receiving corresponding drugs. Serum total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-- C）, low density lipoprotein cholesterol （LDL- C）, and body weight were measured before medication and at 2 and 4 weeks after medication, respectively. RESULTS： Treatment with TMCI at low and high doses showed insignificant impact on mice growth （body weight） . Compared with before medication, TMCI treatment group showed increase in HDL-C level but de- crease in TG, TC and LDL- C levels （P〈 0.05 or P 〈 0.01）, however, these effects were lower than CLST. CONCLUSION： TMCI has good biosecurity in mice and it has certain beneficial effect on hyperlipemia model rats after oral administration.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第34期2655-2657,共3页
China Pharmacy
基金
天津市自然科学基金资助项目(043610611)
关键词
碘化壳聚糖季铵盐
考来烯胺
高脂血症
大鼠
小鼠
急性毒性
降脂作用
N-trimethyl chitosan iodide
Cholestyramine
Hyperlipidemia
Rat
Mouse
Acute toxicity
Lipid - lowering effect
