摘要
室温下,稀土甲基磺酸盐催化苯乙酮、芳香醛和芳香胺的Mannich反应,三组分"一锅法"合成了23种β-氨基酮衍生物(其中4种为新化合物),其结构经1H NMR,IR和元素分析确证。比较了甲基磺酸镧、亚铈、镨、钕、镱的催化活性,结果表明其催化活性接近;催化剂可重复使用。
Twenty-three β-amino ketone derivatives（four new compounds） were synthesized by three components one-pot Mannich reaetion of acetophenone, aromatic aldehydes and aromatic amines using rare earth methylsulfonate as the catalyst at room temperature. The structures were characterized by 1H NMR, IR and elemental analysis. The catalytic activities of La, Ce（ Ⅲ）, Pr, Nd and Yb methanesulfonates were compared with each other, and the results showed that they possessed similar activities. The catalysts could he recovered and reused many times without distinct loss of their catalytic activities.
出处
《合成化学》
CAS
CSCD
北大核心
2009年第6期692-695,共4页
Chinese Journal of Synthetic Chemistry
基金
辽宁省教育厅科学技术研究资助项目(2009A033)
