摘要
目的：对盐酸特拉唑嗪胶囊的人体内生物利用度进行研究。方法：单剂量口服盐酸特拉唑嗪胶囊和片剂２ｍｇ。血药浓度采用ＨＰＬＣ测定，数据用３Ｐ８７计算药动学参数。结果：盐酸特拉唑嗪胶囊剂的药动学参数：Ｋａ为８．２±４．０ｈ－１，Ｔ１／２为８．２±２．５ｈ，Ｔｍａｘ为０．６１±０．１１ｈ，Ｃｍａｘ为４３．５±８．５ｎｇ·ｍｌ－１，ＡＵＣ为３６７．４±３４．６ｎｇ·ｈ·ｍｌ－１；盐酸特拉唑嗪片剂的药动学参数：Ｋａ为６．４±７．４ｈ－１，Ｔ１／２为７．４±２．１ｈ，Ｔｍａｘ为０．９±０．４ｈ，Ｃｍａｘ为４３．１±４．８ｎｇ·ｍｌ－１，ＡＵＣ为３７１．３±４４．４ｎｇ·ｈ·ｍｌ－１。结论：两种剂型的药物动力学参数之间差异均无显著性（Ｐ＞０．０５），胶囊剂的相对生物利用度为９９．８８％。
Objective:Pharmacokinetics and bioavailability of terazosin capsules and tablets were compared in 9 healthy volunteers after single dose oral adminstration.Methods:The blood levels of terazosin were determined by RP HPLC.The 3P87 program was used for the calculation of pharmacokinetic parameters.Results:Rate constants K a were 8.2±4.0 and 6.4±0.4 h -1 ,rate constants T 1/2 were 8.2±2.5 and 7.4±2.1 h.Peak plasma levels of capsules and tablets reached 43.5±8.5 and 43.1±0.8 ng·ml -1 ,at 0.61±0.11 and 0.94±0.39 h respectively.The AUC were 367.4±34.6 and 371.3±44.4 ng·h·ml -1 respectively.Conclusion:The pharmacokinetic parameters obtained from the study showed no significantly difference between two formulations ( P > 0.05 ).The relative bioavailability of capsules was 99.88% compared with the tablet.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1998年第12期531-533,共3页
Chinese Journal of Hospital Pharmacy
