摘要
目的探讨1,6-二磷酸果糖(FDP)对新生儿缺氧缺血性脑病(HIE)合并心肌损害的疗效。方法将62例HIE合并心肌损害患儿随机分为治疗组32例对照组30例。对照组采用常规治疗,治疗组加用FDP250mg/(kg.d)静脉滴注,10天为1疗程,入院12h内及治疗后查血清肌酸激酶(CK)及同工酶(CK-MB)。观察两组患儿临床症状及体征消失情况,心电图变化及治疗后CK、CK-MB的变化。结果治疗组临床症状体征消失快,血清CK、CK-MB恢复正常率高,与对照组比较差异显著。结论外源性FDP对中重度HIE合并心肌损害有一定的治疗作用,有助于心脑功能恢复。
Objective To investigate the effect of 1,6 -diphosphate （FDP） on neonatal hypoxic -ischemic encephalopathy （HIE） combined with myocardial damage. Methods 62 cases of HIE in newborn with myocardial damage were randomly divided into two groups：32 cases of the treatment group and 30 cases of the control group. Control group were giren conventional treatment and the treatment group were giren FDP 250mg / （kg . d） by intravenous drip for 10 days for 1 course of treatment. Each case was tested serum ereatine kinase （CK） and isoenzyme （ CK - MB） within hospitalization 12 hours and after treatment. The two groups were observed with clinical symptoms and signs disappeared, the ECG changes and CK, CK - MB changes. Results Clinical signs and symptoms of treatment group disappeared soon, and serum CK, CK -MB returned to normal rate is high compared with the control group significantly. Conclusion Exogenous FDP has a certain therapeutic effect on moderate to severe HIE with myocardial damage, contributes to recovery of heart and brain function.
出处
《医学研究杂志》
2009年第9期103-105,共3页
Journal of Medical Research
