摘要
目的建立听力正常婴儿短音听性脑干反应（tone—pip ABR）和听觉稳态反应（auditory steady state response，ASSR）反应阈的正常参考值，研究其听觉发育的生物学规律，并比较两种听力检测技术的频率特性。方法选取0—6月龄听力正常婴儿80例（160耳），按月龄分为四组：新生儿组、42d组、3月龄组和6月龄组，每组20例（40耳），男女例数均等，分别记录其短声ABR的潜伏期及在0．25、0．5、1、2、4、8kHz频率范围内tone—pipABR和ASSR的反应阈。结果在70dB正常听力级短声刺激下，短声ABRⅠ、Ⅲ、V波潜伏期、Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ-Ⅴ波间期随月龄增加逐渐缩短，波Ⅰ于42d前、波Ⅲ于3个月前发育变化显著。tone—pipABR波形与短声ABR相似，Ⅰ、Ⅲ、Ⅴ波潜伏期随频率增加逐渐缩短，波形分化逐渐清晰。不同频率、不同月龄tone—pip ABR和ASSR反应阈差异具有统计学意义（P值均〈0．05）。除0．25kHz外，其余频率tone—pip ABR反应阈均低于ASSR。不同月龄tone—pip ABR和ASSR听力曲线形状相似。结论0—6月正常婴儿tone—pip ABR的潜伏期和波间期随月龄增加逐渐缩短，而反应阈无明显变化。tone—pip ABR和ASSR均有稳定的频率特异性，tone—pip ABR反应阈低于ASSR，可能更接近主观纯音听阈。
Objective To estimate tone-pip auditory brainstem response （tone-pip ABR） and auditory steady-state response （ASSR） thresholds to follow the development of heating in four groups of normal babies through the first 6 month of life and to make a comparison between the tone-pip ABR and ASSR for 0. 25 - 8 kHz frequency range at different groups. Methods The tone-pip ABR and ASSR were recorded in four groups of normal hearing infants （ 160 ears） at the age of 2 -4 day,6 weeks, 3-month and 6- month. Tone-pip ABR and ASSR thresholds were established in 0. 25,0. 5,1,2,4 and 8 kHz stimuli. Results For click ABR, the wave latency of Ⅰ , Ⅲ, Vand inter-wave latency of Ⅰ -Ⅲ,Ⅲ-Vand Ⅰ -Ⅴ decreased as the age increase. The developmental changes were obvious in wave Ⅴ and m before 6 weeks and 3 months respectively. Tone-pip ABR had the similar waveform as the click ABR. With the frequency increasing, their waveforms and wave lateneies of Ⅰ, Ⅲ and Ⅴ were getting better and shorter respectively. There was significant difference between the thresholds of tone-pip ABR and ASSR （ all P 〈 0. 05）. The tone-pip ABR thresholds were significantly lower than those of ASSR from 0. 5 to 8 kHz. Both ASSR and tone-pip ABR had similar andiograms for different age of infants with normal heating. Conclusions The longitudinal findings presented in this study suggest that with the maturational development , the wave latency of Ⅰ, Ⅲ, Ⅴand inter-wave latency of Ⅰ -Ⅲ, Ⅲ-Ⅴ and Ⅰ -Ⅴ of tone-pip ABR decrease as the age increase, while the hearing sensitivity have no changes. Both tone-pip ABR and ASSR have stable frequency specificity. Compared to the ASSR, tone-pip ABR have lower response threshold and maybe nearer to the hearing level of the infant.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2009年第11期888-892,共5页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金
济南市科技局科技明星计划（20080114）
济南市卫生局科技项目计划（2008-24）
关键词
诱发电位
听觉
脑干
诱发反应
听觉
婴儿
Evoked potentials, auditory, brain stem
Evoked potentials, auditory
Infant
