摘要
目的了解2009年我国首例甲型H1N1流感二代病例的流行病学、临床、病原学检查特点及预后转归。方法对患者流行病学及临床资料进行回顾性分析,并采用实时荧光聚合酶链反应测定甲型H1N1流感病毒核酸。结果患者与甲型H1N1流感输入病例接触1天后发病。以发热、咽痛、咳嗽起病,白细胞及CD4+T淋巴细胞计数降低,无肺炎等并发症。多级机构检测咽拭子甲型H1N1流感病毒核酸阳性确诊甲型H1N1流感。RT-PCR测序证实其病毒核苷酸序列与一代输入病例的一致,同源性为100%。经奥司他韦抗病毒及对症治疗痊愈出院。结论本病例的传染源明确,为我国首例报告的甲型H1N1流感二代确诊病例,其临床表现轻,病情恢复快。未发生院内感染,早隔离早诊断等防控措施有效。
Objective To investigate the epidemiological,clinical and pathogenic characteristics and the prognosis of the first case of second-generation novel influenza A /H1N1 infection in China.Methods Epidemiological and clinical data of the patient were analyzed retrospectively.The novel influenza A /H1N1 viral RNA was detected by using real-time fluorescent polymerase chain reaction（RT-PCR）.Results Epidemiological evidence indicated that the disease symptoms were developed one day after the contact with a novel influenza A/H1N1 infected patient. The symptoms included fever,sore throat and slight cough. The number of leukocytes and CD4＋ T lymphocytes in peripheral blood was also decreased. Influenza A/H1N1 RNA was detected and confirmed by various testing laboratories. The viral RNA was 100% homology with the virus causing the first-generation infection. The patient was recovered after treatment with Osehamivir and general therapy. Conclusions The first case of second-generation infection by the novel influenza A/H1NI was reported in China in 2009. The source of infection was established. This patient was clinically mild and recovered quickly. The measures used for patient isolation and the disease prevention are effective.
出处
《热带医学杂志》
CAS
2009年第10期1099-1101,1129,共4页
Journal of Tropical Medicine
基金
国家科技支撑计划(甲型H1N1流感联防联控应急科研项目)
