摘要
【目的】观察中药制剂银屑灵片治疗寻常型银屑病的临床疗效。【方法】将纳入研究的48例寻常型银屑病患者,按随机化原则分为对照组和治疗组各24例。治疗组给予口服银屑灵片(由生地黄、当归、赤芍、川芎、紫草、莪术、金粟兰、土茯苓、乌梅、甘草等组成)治疗,对照组给予口服阿维A胶囊治疗,同时两组均外用本院制剂肤必润。两组均以4周为1个疗程,共治疗2个疗程。参照银屑病患者皮损程度评分(PASI)比较两组的临床疗效,并记录药物不良反应,检测血清干扰素-γ(IFN-γ)水平。【结果】(1)第1疗程(4周)后,两组疗效比较差异有显著性意义(P<0.05),提示阿维A胶囊起效较银屑灵片快;第2疗程(8周)后,两组疗效比较差异无显著性意义(P>0.05),说明两组长期疗效相仿。(2)治疗4周后,两组患者血清IFN-γ水平均有显著性降低(与治疗前比较,P<0.05),治疗前后差值比较差异也有显著性意义(P<0.05)。治疗8周后,两组患者血清IFN-γ水平下降更显著(与治疗前比较,P<0.01),但治疗前后差值比较差异无显著性意义(P>0.05)。(3)两组在皮肤干燥、腹部不适、唇干、肝肾功能异常等不良反应方面差异均有显著性意义(P<0.05或P<0.01),提示银屑灵片的副作用较阿维A胶囊少。【结论】银屑灵片治疗寻常型银屑病的疗效与阿维A胶囊相仿,但副作用较阿维A胶囊少。其作用机制可能与银屑灵片能降低患者血清IFN-γ水平有关。
Objective To observe the efficacy of Yinxieling Tablets （YT） for the treatment of psoriasis vulgaris （PV）, and to explore its therapeutic mechanism. Methods Forty-eight PV patients were equally randomized into two groups. The two groups received external application of Fubirun ointment. Additionally, the treatment group received oral use of YT （mainly composed of Radix Rehmanniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Arnebiae seu Lithospermi, Rhizoma Curcumae, Herba Chloranthi Spicati,Rhizoma Smilacis Glabrae, Fructus Mume, Radix Glycyrrhizae, etc. ） , and the control group recewell oral use of Acitretin Capsules. Four weeks constituted one treatment course, and the treatment in both groups lasted 2 courses. After treatment, the relief of symptoms and signs in both groups was evaluated by Psoriasis Area and Severity Index （PASI） scoring, the side effects were monitored, and serum interferon-gamma （IFN-γ） level was measured. Results （ 1 ） At the end of the first treatment course, the therapeutic effect in the treatment group was better than that in the control group （P 〈 0. 05） ; at the end of the second treatment course, the difference of the therapeutic effect between the two groups was insignificant （ P 〉0. 05 ）. （2） After one treatment course, serum IFN-γ level was decreased in both groups （P 〈 0. 05 compared with that before treatment）, and the decrease was obvious in the treatment group （P 〈 0. 05）. After two treatment courses, serum IFN-γ level was decreased obviously in both groups （ P 〈 0.01 compared with that before treatment）, but the decrease was similar in the two groups （ P 〉 0. 05 ）. （3） The adverse effects of dry skin, abdominal discomfort, dry lips and abnormal hepatic and renal function were not obvious in the treatment group （P 〈 0.05 or P 〈 0.01 compared with those in the control group）. Conclusion The therapeutic effect of YT for the treatment of PV is similar to that of Acitreti
出处
《广州中医药大学学报》
CAS
2009年第6期520-522,525,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药管理局科研课题(编号:2050033)
