期刊文献+

复方甘草甜素脂质体防治大鼠脂肪肝性肝纤维化 被引量:3

Therapeutic effects of compound glycyrrhizin liposome on fibrosis of the rats with nonalcoholic steatohepatitis
原文传递
导出
摘要 近年来,非酒精性脂肪肝和非酒精性脂肪性肝炎(NASH)的发病率增高,由其引起的肝纤维化和肝硬化发病率也有上升趋势。但因其发病机制复杂,迄今为止未找到有效的治疗药物。甘草甜素有抗炎、免疫调节、保肝作用,被用于治疗各种急慢性肝损伤。但因有类激素样不良反应,使其应用受到一定限制。本研究对高脂饮食诱发的NASH大鼠给予复方甘草甜素脂质体治疗,另以复方甘草甜素和丹参作为对照药物,观察前者对大鼠NASH和肝纤维化的疗效。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2009年第11期877-878,共2页 Chinese Journal of Hepatology
基金 深圳市科技局项目(200404088)
关键词 甘草 脂质体 大鼠 脂肪肝 肝硬化 Glycyrrhizia uralensis Liposomes Rats Fatty liver Liver cirrhosis
  • 相关文献

参考文献4

二级参考文献97

  • 1胡国平,刘凯,赵连三.多烯磷脂酰胆碱(易善复)治疗酒精性肝病和脂肪肝的系统评价[J].肝脏,2005,10(1):5-7. 被引量:108
  • 2范建高.脂肪肝促发代谢紊乱和动脉硬化的机制[J].诊断学理论与实践,2007,6(2):108-110. 被引量:18
  • 3[9]Uesugi T, Froh M, Arteel GE, Bradford BU, Wheeler MD, Gabele E, Isayama F, Thurman RG. Role of lipopolysaccharidebinding protein in early alcohol-induced liver injury in mice. J Immunol2002; 168:2963-2969 被引量:1
  • 4[10]Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, Grunfeld C. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 1999; 276: R136-R142 被引量:1
  • 5[11]Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, Desimone C, Song XY, Diehl AM. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003; 37:343-350 被引量:1
  • 6[12]Hug H, Strand S, Grambihler A, Galle J, Hack V, Stremmel W,Krammer PH, Galle PR. Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells. J Biol Chem 1997; 272:28191-28193 被引量:1
  • 7[13]Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis.Gastroenterology 2003; 125:437-443 被引量:1
  • 8[14]American Gastroenterological Association medical position statement: nonalcoholic fatty liver disease. Gastroenterology 2002; 123:1702-1704 被引量:1
  • 9[15]Andersen T, Gluud C, Franzmann MB, Christoffersen P. Hepatic effects of dietary weight loss in morbidly obese subjects.J Hepatol1991; 12:224-229 被引量:1
  • 10[16]Luyckx FH, Scheen AJ, Desaive C, Dewe W, Gielen JE, Lefebvre PJ. Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity. Diabetes Metab 1998;24:355-361 被引量:1

共引文献1567

同被引文献17

引证文献3

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部