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卡培他滨联合奈达铂治疗进展期胃癌临床研究 被引量:3

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摘要 目的观察卡培他滨(CAPE)联合奈达铂(NDP)治疗进展期胃癌的临床疗效、不良反应及生活质量的改善情况。方法选择晚期胃癌患者38例。应用CAPE1000mg/m2,2次/d,口服,第1~14天;DNP80mg/m2,加入0.9%氯化钠溶液500ml中静脉滴注2h,第1天。21d为1周期,连用2个周期后评价疗效。结果全组38例均可评价疗效及不良反应,总有效率63.2%,平均生存期(MST)9.8个月,无进展生存期(TTP)8.2个月。主要不良反应为骨髓抑制,Ⅲ~Ⅳ度血白细胞降低6例(15.8%),Ⅲ~Ⅳ度血小板下降5例(13.2%)。消化道反应轻,未发现肾功能损害。结论卡培他滨联合奈达铂治疗晚期胃癌,疗效肯定,不良反应少,生活质量改善明显,尤其对老年患者耐受性好。
出处 《河北医药》 CAS 2009年第19期2583-2584,共2页 Hebei Medical Journal
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