摘要
目的观察LASIK术中应用糖皮质激素预防弥漫性板层角膜炎(diffuse lamellar keratitis,DLK)的临床效果。方法将214例(428眼)接受LASIK的近视患者分为2组,试验组105例(210眼),在LASIK术中局部用糖皮质激素(0.01 g.L-1地塞米松)进行角膜瓣层间冲洗;对照组109例(218眼)用平衡盐液进行冲洗,观察1个月。结果试验组DLK的发病率为4.76%(10眼),全部为I期;对照组为15.14%(33眼),其中Ⅰ期占78.79%(26眼),Ⅱ期占18.19%(6眼),Ⅲ期3.02%(1眼),2组比较差异有显著统计学意义(P<0.01)。术后2组患者的裸眼视力、平均屈光度比较差异无统计学意义(P>0.05),术后最佳矫正视力均未见下降。结论LASIK术中应用0.01 g.L-1的地塞米松进行角膜瓣层间冲洗,能够明显降低DLK的发病率,是一种安全、有效的预防方法。
Objective To evaluate the clinical effects of glucocorticoid on preventing diffuse lamellar keratitis（DLK） during laser in situ keratomileusis（LASIK）.Methods A total of 214 myopia patients（428 eyes）,who received LASIK,were divided into two groups,experimental group（105 cases,210 eyes） and control group（109 cases,218 eyes）.The former was treated with local application of glucocorticoid rinsing interlaminar of corneal valve during LASIK,and the latter used balanced salt solution.All patients were observed for 1 month.Results The incidence rate of DLK was 4.76%（10 eyes） in experimental group,all were at grade I;And the incidence rate of DLK was 15.14%（33 eyes） in control group,78.79%（26 eyes） at grade I,18.19%（6 eyes） at grade II and 3.02%（1 eye） at grade Ⅲ.There was statistical difference between the two groups（P〈0.01）.The postoperative uncorrected visual acuity and average diopter had no significant difference between the two groups（P〉0.05）.Best corrected visual acuity didn＇t decrease postoperatively.Conclusion Rinsing interlaminar of corneal valve with 0.01 g·L-1 dexamethasone is a safe and effective way to lower the incidence rate of DLK.
出处
《眼科新进展》
CAS
北大核心
2009年第11期846-848,共3页
Recent Advances in Ophthalmology
