摘要
通过建立壳聚糖胃滞留-漂浮微球(CGRM)缓释性能的GM(1,1)模型、零级释放动力学模型(ZODM)、Higuchi模型和Ritger-Peppas(RPeppas)模型,并对各模型的模拟和预测性能进行了研究。结果表明四个模型均能较好地模拟和预测CGRM的缓释性能,模拟精度与预测精度优劣顺序相同,依次为:GM(1,1)>Higuchi>ZODM>RPeppas,其中GM(1,1)模型最优。
To demonstrate the release property of Chitosan Gastric Retenting-floating Microspheres（CGRM）,the GM（1,1） model, Zero Order Dynamic Model（ZODM）,Higuchi models and Ritger-Peppas（RPeppas） model are established.By analyzing the descriptive ability and predictive ability of the models,the results enunciate that all of them can perfectly simulate the release property.Both of the simulation accuracy and the prediction accuracy are summarized in an order of good to poor as GM（1,1）, Higuchi,ZODM,RPeppas,and the GM（1,1） model is the best.
出处
《计算机工程与应用》
CSCD
北大核心
2009年第33期213-215,248,共4页
Computer Engineering and Applications
基金
教育部科学技术研究重点项目No.205074
安徽省优秀青年科技基金项目No.06046099
安徽高校省级自然科学研究项目No.KJ2007B071~~
关键词
动力学模型
灰色系统理论
胃滞留-漂浮微球
缓释
壳聚糖
dynamic model
grey system theory
gastric retenting-floating microspheres
sustained-release
chitosan
