摘要
目的探讨原发性高血压患者血清基质金属蛋白酶(MMP-2)、C反应蛋白(CRP)与颈动脉粥样硬化斑块稳定性的关系。方法对94例原发性高血压患者行颈动脉超声检查,分别测定并记录颈动脉内中膜厚度(IMT)、斑块形态、回声强度、斑块数量。根据超声病理形态分为不稳定斑块组(A组)35例、稳定斑块组(B组)31例和无斑块组(C组)28例。采用酶联免疫双抗体夹心法(ELISA)测定原发性高血压患者血清MMP-2、免疫比浊法测定血清CRP水平。结果 A组血清MMP-2、CRP显著高于B组和C组(P<0.01);B组血清MMP-2、CRP显著高于C组。A组和B组血清MMP-2与CRP呈正相关(r=0.597,P<0.01)。结论原发性高血压患者血清MMP-2、CRP水平与颈动脉斑块稳定性有关。
Objective To explore the correlation between matrix metalloproteinase -2 and C -reactive protein（CRP） and carotid atherosclerosis. Methods 94 patients with essential hypertension were investigated and divided into three group： unstable plaque group （ group A） with 35 cases, stable plaque group （ group B） with 31 cases, no plaque group （ group C ） with 28 cases by the nature of ultrasonography of carotid atherosclerosis plaque. Color Doppler Ultrasonography was performed to detect the level of carotid intima - media thickness（IMT）. Serum MMP - 2 was evaluated using ELISA method. Serum CRP was evaluated using Immunological turbidity. Results Serum MMP- 2 and CRP concentration was significantly elevated in group A, comparing with that in B and C group （P 〈 0.01 ）. The concentration of Serum MMP - 2 had a positive relation to that of CRP in A group（ r = 0. 597, P 〈 0.01 ）. Conclusion The concentration of Serum MMP- 2 and CRP has a positive relation to the carotid atherosclerosis.
出处
《医学研究杂志》
2009年第10期42-44,共3页
Journal of Medical Research
