摘要
目的观察益肾通络方对自发性膜性肾病(IMN)患者24h尿蛋白(24hTP)定量、血浆白蛋白(Alb)、组织纤溶酶原激活因子(t-PA)、Ⅰ型纤溶酶原激活因子抑制因子(PAI-1)及内皮素-1(ET-1)的影响,探讨其部分作用机制。方法72例经肾脏穿刺病理诊断为IMN(病理分期Ⅰ及Ⅱ期)、肾功能正常的患者,随机分为治疗组和对照组。对照组给予基础治疗,治疗组加服益肾通络中药。另设健康志愿者30例为健康组。结果治疗前,治疗组及对照组与健康组比较,PAI-1及ET-1均显著增高(均P<0.01),t-PA显著降低(P<0.01);治疗后与对照组比较,治疗组24hTP明显降低(P<0.01),Alb和t-PA显著升高(P<0.01,P<0.05),PAI-1和ET-1显著下降(P<0.05,P<0.01)。结论益肾通络方能够降低IMN(Ⅰ、Ⅱ期)患者24hTP、PAI-1及ET-1,升高Alb、t-PA水平。
Objective By observing the effect of Yishentongluo recipe on 24 h urine protein（24 h TP）,plasma-albumin（Alb）,tissue plasminogen activator（t-PA）,type-1 plasminogen activator inhibitor（PAI-1） and endothelin-1 to explore the action mechanism.Methods 72 disagnosed as idiopathic membranous nephropathy（IMN Ⅰ,Ⅱ phase） by kidney paracentesis pathological diagnosis with normal kidney function were randomly divided into treatment and control groups.The control group was given basic treatment,treatment group was added Yishentongluo recipe.The other 30 healthy control was as healthy group.Results Before treatment,compared with healthy group,the other two groups had the enhanced PAI-1,ET-1（all P〈0.01）,the decreased t-PA（P〈0.01）.After treatment,compared with control group,the treatment group had the decreased 24 h TP,PAI-1 and ET-1（P〈0.01,P〈0.05,P〈0.01）,the enhanced Alb,t-PA（P〈0.01,P〈0.05）.Conclusions Yishentongluo recipe could descend 24 h TP,PAI-1 and ET-1,and enhance Alb,t-PA level of IMN patients.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2009年第20期2564-2565,共2页
Chinese Journal of Gerontology
基金
河北省科技厅科技攻关课题(No.08206115D)
