摘要
目的:探讨ICP患者的血清游离E3和β-HCG及IgG、IgM、IgA、C3、C4和外周血淋巴细胞亚群(CD4+、CD8+和CD4+/CD8+)水平的变化与患者发病的关系。方法:游离E3和β-HCG两项指标采用放射免疫分析,IgG、IgM、IgA、C3和C4采用免疫比浊法。CD4+、CD8+测定采用流式细胞术。结果:ICP患者组游离E3和β-HCG水平呈前者高于对照组非常显著(P<0.01);后者则略高于对照组,但并无统计学意义(P>0.05);五项体液免疫学指标呈IgG水平低于对照组(P<0.01);而IgM、IgA、C3、C4四项指标水平与对照组比较均无显著差异(P均>0.05)。淋巴细胞亚群测定呈CD4+T细胞水平与对照组比较无显著差异(P>0.05);而CD8+T细胞水平显著高于对照组(P<0.05);CD4+/CD8+两种T淋巴细胞比值则显著低于对照组(P<0.05)。结论:ICP患者血清10项指标的测定对于了解和认识其发病机理及预估病情有帮助。
Objective To study the changes of serum levels of free E3,β-HCG,IgG,IgM,IgA,C3,C4 and peripheral blood CD4＋,CD8＋ contents in patients with ICP.Methods Serum free E3,β-HCG（with RIA）,IgG,IgM,IgA,C3 and C4（with immuno-turbidity assay） levels and peripheral blood CD4＋,CD8＋ contents（with flow-cytometry） were determined in 40 patients with ICP and 40 normal pregnant controls.Results Serum free E3 levels in patients with ICP were significantly higher than those in controls（P〈0.01） while the β-HCG levels were only insignificantly higher（P〉0.05）.The serum IgG contents in patients with ICP were significantly lower than those in controls（P〈0.01）,while the serum IgM,IgA,C3 and C4 contents in patients with ICP were not significantly different from those in controls（P〉0.05）.CD4＋ percentages in the patients were not significantly different from those in controls while the CD8＋ percentages were significantly higher（P〈0.05）,with a significantly lower CD4＋/CD8＋ ratio.Conclusion Significant changes of contents of serum free E3 and IgG and a lower CD4＋/CD8＋ ratio were present in patients with ICP,the exact mechanisms were not determined yet.
出处
《放射免疫学杂志》
CAS
2009年第4期315-317,共3页
Journal of Radioimmanology
关键词
肝内胆汁淤积症
游离E3
免疫功能指标
intrahepatic cholestasis of pregnancy, free estriol, immune function
