摘要
为探索小剂量米非司酮用于紧急避孕的效果,观察291例健康、月经规律妇女,在避孕失败或无保护的性生活后72小时内服药,并随机分为3组,组1(n=99)单次口服25mg米非司酮;组Ⅱ(n=92)单次服用10mg米非司酮;组Ⅲ(n=100)单次服用5mg米非司酮。3组共4例失败。避孕有效率分别为83.8％、84.92％和70.5％,三组间无明显差异。服低剂量米非司酮后副反应发生率低,对月经影响小。观察5例服用5mg米非司酮妇女子宫内膜形态,3例出现子宫内膜发育不同步,2例变化不明显。结果表明,5mg米非司酮用于紧急避孕,临床上虽有一定成功率,但对子宫内膜影响不肯定,尚需进一步研究,故应谨慎用于临床。
Two hundred and ninety - one women were treated with the different doses of antiprogestins, Mifepristone 25mg, 10mg, 5mg, within 72 hours after unprotected intercourse or contraceptive failure. Endometrial morphology was examined in five subjects of the 5mg group. The contraceptive effective rates were 83. 8%, 84. 92% and 70. 5% respectively. There were four pregnant women in the end of study. The pregnancy rates were not significantly different among the 3 groups.The side effects were mild, the endometrial morphological analysis revealed a retardation of development after the treatment in two subjects of the 5mg group, whereas the endometrial development in phase with the cycle in the remaining subjects. The results suggested that caution should be exercised in the use of 5mg of Mifepristone administered within 72 hours after unprotected intercourse.
出处
《中国计划生育学杂志》
1998年第8期343-345,共3页
Chinese Journal of Family Planning
关键词
米非司酮
紧急避孕
子宫内膜
避孕
Mifepristone emergency contraception endometrium
