摘要
目的:通过对确诊的母儿血型不合患者辨证分型治疗,检测外周血治疗前后抗A或抗B抗体及红细胞免疫复合物花环率(RICR)和红细胞受体花环率(RC3bR)等,了解以茵陈蒿汤为主的辨证方疗效及其机制。方法:按13随机将确诊为母儿血型不合的患者分为对照组及观察组,再对观察组进行辨证分为湿热组(SR)、湿热兼脾气虚组(SR+PQX)及湿热兼肾气虚组(SR+SQX),用相应方药治疗,1个月为1疗程,治疗前后测定外周血抗A或抗B抗体及RICR,RC3bR等。结果:茵陈蒿汤原方治疗的对照组21例抗A或抗B抗体,5例降为164,4例降为132;辨证方观察组63例中33例降至164,20例降为132。对照组及观察组治疗前后RICR(%)分别为(19.43±5.29,19.57±6.50;20.59±7.96,23.77±5.12),RC3bR(%)分别为(11.62±4.16,12.42±6.60;11.93±4.10,13.96±6.40)。两者中观察组治疗后与治疗前,观察组治疗后与对照组治疗后比较,差异有统计学意义(P<0.05)。但辨证方之间治疗后差异无统计学意义(P>0.05)。结论:以辨证方为主的观察组对于降低母儿血型不合患者外周血中抗A或抗B抗体,升高红细胞RICR以及RC3bR均优于以茵陈蒿汤原方为主的对照组。
Objective： Through treatment based on differentiation of symptoms and signs and classification of definited patients of maternofetal blood group incompatibility, detecting anti-A or Anti-B antibody and erythrocyte immune complex chaplet rate（RICR） and erythrocyte receptor chaplet rate（RC3bR） , etc, to observe the therapeutic effect and mechanism of prescriptions mainly with Yinchenhao Decoction. Methods： Patients definited maternofetal blood group incompatibility were divided into control group and observation group according to random principle in 1：3 ratio. Then, observation group was divided into moist heat group（SRG）, moist heat and deficiency of spleen qi group （SR＋PQXG） and moist heat and deficiency of kidney qi group（SR＋SQXG） according to syndrome differentiation. Corresponding prescriptions were used, every 30 doses 1 course. Before and after treatment, the anti-A or anti-B antibody and RICR, RC3bR were detected in peripheral blood. Results： In Yinchenhao Decoction group with 21 cases, the anti-A or anti anti-B antibody decreased, including 5 case （1：64） and 4 case （1：32）. In group of syndrome differentiation with 63 cases, the anti-A or anti anti-B antibody decreased, including 33 case（l：64） and 20 case （1：32）. Before and after treatment, RICR of control group and observation group were（19.43±5.29）, （19.57±6.50）and （20.59± 7.96）, （23.77±5.12）, respectively. RC3bR were（11.62±4.16）, （12.42±6.60）and（11.93±4.10）, （13.96±6.40）respectively. There was significant difference of before and after treatment in obserbation group（P〈0.05）, and after treatment, there was obvious difference between observation group and control group（P〈0.05）. But after treatment, there was on statistical significance among observation groups（P〉0.05）. Conclusion： In cutting down anti-A and anti-B antibody, and increasing RICR and RC3bR field, the observation groups were better than control group.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2009年第11期1514-1516,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
广东省中医药强省科技计划资助课题(No.2060144)
关键词
母儿血型不合
抗体
红细胞免疫
茵陈蒿汤
湿热
Maternofetal blood group incompatibility
Antibody
Erythrocyte immunity
Yinchenhao Decoction
Humid-heat
