视神经损伤后视网膜神经节细胞保护研究进展被引量：2

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摘要外伤、肿瘤、炎痒和缺血均可造成视神经损伤，从而导致患者视力严重受损。视神经损伤后大量视网膜神经节细胞（retinalganglion cells，RGCs）继发死亡，是不可逆视觉功能减退的主要原因。减缓或抑制视神经损伤后RGCs的继发死亡是有效治疗视神经损伤和促进视觉功能恢复的基础。最近视神经损伤后RGCs的保护研究取得了一系列进展，

作者吕燕春吕立权卢亦成

机构地区浙江省余姚市卫生进修学校上海长征医院神经外科

出处《现代实用医学》 2009年第10期1147-1149,共3页 Modern Practical Medicine

基金国家自然科学基金资助项目编号:30600635

关键词视网膜神经节细胞视神经损伤节细胞保护 RGCS cells 功能减退功能恢复有效治疗

分类号 R775 [医药卫生—眼科] R774.6 [医药卫生—临床医学]

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1Hare W,,WoldeMussie E,Lai R,et al.Effi-cacy and safety of memantine,an NMDA-type open-channel blocker,for reductionofretinal injury associated with experimentalglaucoma in rat and monkey[].Survey of Ophthalmology.2001 被引量：1
2Malik JM,ShevtsovaZ,BahrM,etal.Long-terminvivoinhibitionofCNSneurodegenera-tion by Bcl-XL gene transfer[].Molecular Therapy.2005 被引量：1
3Parrilla-ReverterG,Agudo M,Sobrado-CalvoP,et al.Effects of different neurotrophicfactors on the survival of retinal ganglioncells after a complete intraorbital nervecrushinjury:a quantitative in vivo study[].Experimental Cell Research.2009 被引量：1
4OkazakiY,MorimotoT,SawaiH.Parametersof optic nerve electrical stimulation affect-ing neuroprotection of axotomized retinalganglion cells in adult rats[].Neurosciences Research.2008 被引量：1
5Dong CJ,Guo Y,Agey P,et al.Alpha2 ad-renergic modulation of NMDA receptor func-tion as a major mechanism of RGC protec-tion in experimental glaucoma and retinalexcitotoxicity[].Investigative Ophthalmology.2008 被引量：1
6Leaver SG,Cui Q,Bernard O,Harvey AR.Cooperativeeffectsofbcl-2andAAV-mediatedexpression of CNTF on retinal ganglion cellsurvival and axonal regeneration in adulttransgenic mice[].European Journal of Neuroscience.2006 被引量：1
7Carmignoto G,Maffei L,Candeo P,et al.Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section[].The Journal of Neuroscience.1989 被引量：1
8Koeberle PD,Ball AK.Neurturin enhances the survival of axotomized retinal ganglion cells in vivo:combined effects with glial cell line-de-rived neurotrophic factor and brain-derived neurotrophic factor[].Neuroscience.2002 被引量：1
9Weise J,Isenmann S,Klocker N,et al.Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo[].Neurobiology of Disease.2000 被引量：1
10Eun-Jin Lee Keun-Young Kim Tae-Hyung Gu Jung-Il Moon In-Beom Kim Mun-Yong Lee Su-Ja Oh and Myung-Hoon Chun.Neuronal nitric oxide synthase is expressed in the axotomized ganglion cells of the rat retina[].Brain Research.2003 被引量：1