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利妥昔单抗联合CHOP方案治疗弥漫性大B细胞淋巴瘤临床观察 被引量:7

Clinic observation with diffuse large B-cell lymphoma treated by combination of rituximab and CHOP
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摘要 目的:观察利妥昔单抗联合环磷酰胺、长春新碱、表柔比星及泼尼松(CHOP方案)治疗弥漫性大B细胞淋巴瘤(DLBCL)的疗效和不良反应。方法:采用利妥昔单抗+CHOP方案对4例DLBCL患者进行联合化疗,21d为1个周期。结果:随访14个月,4例患者均处于完全缓解中,无明显不良反应。结论:利妥昔单抗联合CHOP方案治疗DLBCL,疗效好,不良反应小。 Objective: To observe the effect and side effect of combination treatment of rituximab, cyclophosphamide, vincristine, epirubicin and prednisone (CHOP) on diffuse large B-cell lymphoma (DLBCL).Methods: Employed combined chemical therapy with rituximab and CHOP to 4 DLBCL patients for 21 d per course. Results: Follow-up of 14 months showed 4 cases were totally relieved without any side effect. Conclusion: Combination treatment of rituximab and CHOP is effective and of little side effect.
出处 《海南医学院学报》 CAS 2009年第11期1398-1399,1402,共3页 Journal of Hainan Medical University
基金 海南医学院科研基金资助学报项目(0020090231)~~
关键词 利妥昔单抗 弥漫性大B细胞淋巴瘤 联合化疗 Rituximab Diffuse large B-cell lymphoma Combined chemical therapy
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  • 3Golay J,Zaffaroni L,Vaccari T,et al.Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis[].Blood.2000 被引量:1
  • 4Ghetie MA,Bright H,Vitetta ES.Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin[].Blood.2001 被引量:1
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