摘要
microRNA（miRNA）是一大类广泛存在于真核细胞当中的长度约22nt的内源性单链非编码RNA，通过与靶基因mRNA的3’非翻译区（3’untranslated region，3’UTR）结合在转录后水平调控靶基因的表达。miRNA作为调控基因表达的重要分子在骨骼肌分化调控中的作用越来越受到关注，阐明miRNA在骨骼肌增殖与分化中的作用机制具有重要的理论意义，同时也可为骨骼肌相关疾病的治疗提供新的思路。文章总结了miRNA，尤其是miR-1、miR-133和miR-206等肌肉特异性miRNA，在调控骨骼肌分化过程中作用机制的研究进展，以便于进一步工作的开展。
microRNA （miRNA） are -22 nucleotides （nt） endogenous single-strand non-coding small RNAs, which mediate post-transcriptional repression of target mRNAs by binding their 3＇UTR. Presently, more and more studies have indicated that miRNA plays important roles in proliferation and differentiation of skeletal muscle. It is of great theoretical significance to elucidate underlying mechanism of miRNA in myogenic differentiation, and of important practical sense to provide new clues for treatment of skeletal muscle related diseases. This review summarizes the most out-standing researches of miRNA, especially muscle-specific miRNA, such as miR-1, miR-133 and miR-206, which are involved in regulation of myogenesis.
出处
《医学分子生物学杂志》
CAS
CSCD
2009年第5期442-446,共5页
Journal of Medical Molecular Biology
基金
国家重点基础研究发展规划（973计划）（No.2005CB522605）
