摘要
以十二烷二酸(1)为原料,与甲醇酯化生成十二烷二酸二甲酯(2),收率为86.5%。化合物2经偶联缩合得1,2-二三甲基硅氧基环十二烯(3),收率为63.1%。利用溴氧化化合物3得到1,2-环十二二酮(4)淡黄色晶体,收率79%,全过程收率达43.1%,是合成1,2-二酮的新方法。目标化合物结构经红外光谱、核磁共振氢谱和碳谱表征确认。
1,2-Cyclododecandione（4） was synthesized from dodecanedioic acid via esterification,acyloin condensation,oxidation in an overall yield of 43.1%.Reaction of dodecanedioic acid with methanol gave dodecanedioic acid dimethyl ester（2） with a yield of 86.5%.Compound 3 was obtained from compound 2 through acyloin condensation and the yield reached up to 63.1%,which was oxidized to compound 4 by bromine water as the oxidation reagent with a yield of 79%.The target compound was a light yellow crystal and was characterized by means of IR,^1H NMR and 13C NMR.
出处
《应用化学》
CAS
CSCD
北大核心
2009年第11期1374-1376,共3页
Chinese Journal of Applied Chemistry
基金
河北省自然科学基金(B200400278)资助项目
关键词
十二烷二酸
偶联缩合
环十二二酮
dodecanedioic acid, acyloin condensation, cyclododecandione
