摘要
以稀土磁性纳米微球Dy:Fe3O4@PHEMA-Tb为载体材料,丝裂霉素C(MMC)为模型药物,在一定条件下制备了具有生物相容性、低毒性等特点的稀土磁性药物微球(MMC-PHEMA-FMPM s).通过正交实验设计考察了制备MMC-PHEMA-FMPMs工艺条件对磁性微球的载药量和包封率的影响,用高效液相色谱(HPLC)测定稀土磁性药物微球的载药量和包封率,固体永磁铁测试稀土磁性药物微球的体外磁响应性.结果表明,稀土磁性纳米微球具有较高的载药量和包封率,体外药物释放受pH影响较大,磁响应性显著,是靶向给药的良好载体.
Rare earth magnetic drug - microspheres MMC - PHEMA - FMPMs with biocompatibility and low poisoness were prepared under a certain condition by taking rare earth magnetic nano -microspheres Dy： Fe3O4 @ PHEMA-Tb as carrier and mitomycin C as pharmaceutical model. The design of orthogonal experiment detected the effect of process conditions of preparation on drug loading and embedding ratio, which of MMC - PHEMA - FMPMs was measured by HPLC and magnetic responsibility by solid permanent magnet. The results show that the rare earth magnetic nano - microspheres has a high drug loading and embedding ratio, a great effect of relaxation ability in vitro on pH, a very remarkable magnetic responsibility and therefore can be used as high - quality drug carrier.
出处
《材料与冶金学报》
CAS
2009年第3期234-240,共7页
Journal of Materials and Metallurgy
基金
山东省自然科学基金资助项目(Q2006F01)
关键词
稀土磁性纳米微球
丝裂霉素C
载药量
包封率
磁响应性
rare earth magnetic nano-microspheres
mitomycin C
drug loading
embedding ratio
magnetic responsibility
