摘要
目的：进一步了解创伤性脑水肿的发生机理和探索其治疗方法。方法：将１８只家兔随机分为３组：标准对照组（组１）、实验对照组（组２）、１，６－二磷酸果糖（ＦＤＰ）治疗组（组３）。取损伤前及损伤后不同时间的颈内静脉血、伤后３ｈ大脑皮质，测定观察指标。结果：组３大脑皮层的丙二醛（ＭＤＡ）含量和水含量、颈内静脉血液中ＭＤＡ浓度均较组２低（Ｐ＜０．０１）；大脑皮层的光、电镜观察显示：组３的损伤程度较组２轻。结论：ＦＤＰ对创伤性脑水肿有一定的治疗作用，表现为：抑制氧化磷酸化过程。
Objective: To understand the mechanisms of traumatic cerebral edema and to seek the new therapy. Method: 18 rabbits were randomly divided into 3 groups: Standard control group 1, experiment control group 2, and FDP group 3. Measured were the Parameters that were collected at different intervals of vein carotis internal samples and cerebral cortical samples 3 hours after injury. Results: The MDA and water concentration of cerebral cortex and venous MDA concentration in group 3 were significantly lower than in group 2 ( P <0.01). The more severe structural damage of cerebral cortical tissue was found in group 2. Conclusion: FDP has some beneficial effects on traumatic cerebral edema.
关键词
脑水肿
药物疗法
二磷酸果糖
家兔
brain edema/TH
malondialdehyde/AN
fructose/TU
cerebral cortex
rabbits
