摘要
目的：探讨脾切除对肝硬变大鼠移植型肝癌的影响。方法：肝硬变大鼠在肝内移植Ｗａｌｋｅｒ－２５６癌肉瘤的同时随机分为切脾组和模拟切脾组，动态观察肝癌直径、肝癌转移率、外周血ＮＫ细胞活性、血小板计数及纤维蛋白原定量。结果：切脾组ＮＫ细胞活性显著低于模拟切脾组，但血小板计数、纤维蛋白原定量、肝癌直径及肝癌转移率显著高于模拟切脾组。结论：脾切除改善了移植型肝癌大鼠的血小板减少症，但抑制了ＮＫ细胞活性。
Objective: To study the effects of splenectomy on the growth of intrahepatic implanted hepatoma in the rats with cirrhosis. Methods: Liver cirrhotic rats with intrahepatic implanted walker 256 carcinosarcoma were randomizedly divided into two groups: splenectomy group and sham operation group. Dynamic changes of natural killer cell activity of peripheral blood, platelet count, fibrinogen, the diameter of implanted hepatoma and metastatic rates after operation were observed. Results: NK activity in splenectomy group was significantly lower than in sham operation group. Platelet count, fibrinogen concerntration, diameter of implanted hepatoma and metastatic rates in splenectomy group were significantly higher than in sham operation group. Conclusions: splenectomy may improve the thrombocytipenia induced by hypersplenism, but inhibit NK activity, accelerate the growth of hepatoma and increase metastatic rates.
