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骨痂中碱性成纤维细胞生长因子的免疫组化定位 被引量:7

Expression of basic fibroblast growth factor in the callus following human facial bone fracture
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摘要 目的:观察碱性成纤维细胞生长因子在人颌面部骨折愈合过程中的表达及量的变化。方法:于颌面部骨折的患者行切开复位内固定术时,取骨断端间骨痂,利用ABC免疫组织化学方法检测了骨折后不同时间碱性成纤维细胞生长因子在骨痂组织中的分布。结果:在骨折修复初期的骨痂中,新生骨基质、未分化间充质细胞、成骨细胞、幼稚的软骨细胞、骨细胞及血管内皮细胞的免疫组化染色均为强阳性。随着骨化的进行及软骨的成熟,成熟钙化的骨基质、处于分化末期的肥大的软骨细胞染色为阴性,成骨细胞、骨细胞及血管内皮细胞仍有部分呈阳性反应,但阳性着色的细胞数及阳性反应程度均较前明显下降。结论:碱性成纤维细胞生长因子参与了人颌面部骨折修复的全过程,在骨折愈合中发挥着重要的作用。 Objective:To investigate the expression of basic fibroblast growth factor (bFGF) in the process of human facial bone fracture healing.Method:Callus samples from the fractured bone stumps were collected when the patients were operated on for internal fixation.Immunohistochemical technic--ABC staining was used to detect the distribution of bFGF in the callus tissue.Result:Positive staining was found in newly formed bone matrix,undifferentiated mesenchymal cells,osteoblasts,premature chondrocytes,osteocytes and endothelials in the early stage callus.Negative reaction was found in the mature and ossified bone matrix and hypertrophic chondrocytes which were in the late stage of differentiation.Weaker staining and fewer bFGF positive cells were observed in the cartilage following the developement of ossification and maturation.Conclusion:bFGF may play a role in the process of human facial bone fracture healing.
出处 《实用口腔医学杂志》 CAS CSCD 北大核心 1998年第4期265-267,共3页 Journal of Practical Stomatology
关键词 骨痂 碱性成纤维细胞 生长因子 颌面部骨折 Jaw Face Fracture Basic fibroblast growth factor Callus
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