摘要
目的：阐明低密度脂蛋白（ＬＤＬ）分子颗粒与脑动脉粥样硬化之间的内在关系。方法：以胆固醇负荷家兔为动物模型，从血浆ＬＤＬ的脂质生化学和超微形态学的角度对其进行动态观察。结果：随着胆固醇负荷时间的增加，血浆ＬＤＬ中脂质过氧化物（ＬＰＯ）和载脂蛋白Ｂ（ＡｐｏＢ）的含量逐渐增加，血浆ＬＤＬ分子颗粒也明显增大。结论：血浆ＬＤＬ分子颗粒的增大可能是引起脑动脉粥样硬化形成的原因之一。因此，膳食结构的改变可以预防和阻止脑动脉粥样硬化的形成。
Objective:This paper was to investigate the association of low bensity lipoprotein(LDL) with cerebral atherosclerosis. Methods:We observed the biochemical and ultrastructural changes of LDL in plasma from rabbits after they were fed with cholesterol. Results: The levels of lipid peroxide(LPO) and apolipoprotein B(ApoB) in plasma increased significantly, and molecular size of LDL also enlarged in the plasma. Conclusions: The change of molecular size in LDL may be one of the causes for cerebral atherosclerosis that can be prevented when the constituents in food are changed.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1998年第5期516-518,共3页
Journal of China Medical University
关键词
脑动脉硬化
胆固醇负荷
血浆
低密度脂蛋白
cholesterol feeding
low density lipoprotein
cerebral atherosclerosis
